1887

Abstract

() is a south-east Asian tree more commonly known as ‘Jarul’. Research on health benefits suggests that the . plant contains phytomolecules that may have antioxidant, anti-diabetic and anti-obesity properties. However, antimicrobial activities have not been reported for this plant. The ability of fruit extract (LSFE) to antagonize cell-to-cell communication, expression of virulence genes and factors, and biofilm formation was evaluated in strain PAO1. Our results suggested that LSFE caused downregulation of quorum sensing (QS)-related genes ( and ) and their respective signalling molecules, -acylhomoserine lactones, without affecting the growth of PAO1. Significant inhibition of virulence factors: LasA protease, LasB elastase, and pyoverdin production, was also recorded. Application of LSFE to PAO1 biofilms increased bacterial susceptibility to tobramycin. These data suggest a possible role for quorum-quenching mechanisms unrelated to static or cidal effects, and also suggest that . could serve as a cost-effective source in the development of new QS-based antibacterial drugs.

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2012-02-01
2020-08-10
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