1887

Abstract

Metal homeostasis is important in all living cells in order to provide sufficient amounts of metal ions for biological processes but to prevent toxic effects by excess amounts. Here we show that the gene product of RSP_2889 of the facultatively photosynthetic bacterium is homologous to CueR, a regulator of copper metabolism in and other bacteria. CueR binds to the promoter regions of genes for a copper-translocating ATPase and for a copper chaperone and is responsible for their high expression when cells are exposed to elevated levels of copper ions. While deletion of RSP_2889 has no significant effect on copper resistance, expression from a low-copy-number plasmid mediates increased sensitivity to copper.

Funding
This study was supported by the:
  • Deutsche Forschungsgemeinschaft (Award Kl563/25-1)
  • Justus Liebig University Giessen
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/content/journal/micro/10.1099/mic.0.051607-0
2011-12-01
2023-02-02
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