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Volume 158, Issue 1

P signal transduction proteins: pivotal players in post-translational control of nitrogenase activity Free

Abstract

The fixation of atmospheric nitrogen by the prokaryotic enzyme nitrogenase is an energy- expensive process and consequently it is tightly regulated at a variety of levels. In many diazotrophs this includes post-translational regulation of the enzyme’s activity, which has been reported in both bacteria and archaea. The best understood response is the short-term inactivation of nitrogenase in response to a transient rise in ammonium levels in the environment. A number of proteobacteria species effect this regulation through reversible ADP-ribosylation of the enzyme, but other prokaryotes have evolved different mechanisms. Here we review current knowledge of post-translational control of nitrogenase and show that, for the response to ammonium, the P signal transduction proteins act as key players.

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2012-01-01
2025-04-23
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PII signal transduction proteins: pivotal players in post-translational control of nitrogenase activity
Microbiology 158, 176 (2012); https://doi.org/10.1099/mic.0.049783-0
/content/journal/micro/10.1099/mic.0.049783-0
/content/journal/micro/10.1099/mic.0.049783-0
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