1887

Abstract

serovar Typhi ( Typhi) is the aetiological agent of typhoid fever in humans. This bacterium is also able to persist in its host, causing a chronic disease by colonizing the spleen, liver and gallbladder, in the last of which the pathogen forms biofilms in order to survive the bile. Several genetic components, including the genes, have been suggested to be involved in the survival of in the gallbladder. In this work we describe how the gene cluster forms a transcriptional unit regulated positively by the cAMP receptor global regulator CRP (cAMP receptor protein). The results obtained show that two CRP-binding sites on the regulatory region of the operon are required to promote transcriptional activation. In this work we also demonstrate that the transcriptional unit is carbon catabolite-repressed in indicating that it forms part of the CRP regulon in enteric bacteria.

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2011-03-01
2020-07-03
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