1887

Abstract

Bacteria acquire iron through a highly specific mechanism involving iron-chelating molecules termed siderophores. The Gram-negative bacterium can utilize siderophores produced by other micro-organisms to facilitate iron uptake. Here we show that a strain deficient in siderophore production can use the siderophore vibriobactin as an iron source. In addition, we identified a gene, PA4156 (), encoding a protein highly homologous to the vibriobactin receptor (ViuA). A mutant in the two endogenous siderophores (pyoverdine and pyochelin) and in was unable to utilize vibriobactin as an iron source. Additionally, preliminary analyses revealed the involvement of vibriobactin, Fur protein and an IclR-type regulator, FvbR (PA4157), in regulation.

Funding
This study was supported by the:
  • Israel Science Foundation (Award 366/07)
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2011-07-01
2021-10-25
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