1887

Abstract

The ability of to act as an opportunistic fungal pathogen is linked to its ability to switch among different morphological forms. This conversion is an important feature of and is correlated with its pathogenesis. Many conserved positive and negative transcription factors regulate morphogenetic transition of . Here, we show the results of functional analysis of , which is an orthologue of the gene. We have cloned which has an ability to complement the . Δ mutant strain growth defect. Interestingly, although disruption of the gene did not affect cell growth in solid and liquid iron-limited conditions, the cell surface ferric reductase activity was significantly decreased. Importantly, deletion of in led to growth of a smooth colony with no peripheral hyphae. Moreover, virulence of an Δ/Δ mutant was markedly attenuated in a mouse model. Our results suggest that Aft2p represents a novel activator and that it functions in ferric reductase activity, morphogenesis and virulence in .

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2010-10-01
2019-10-19
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