1887

Abstract

Rifampicin and its derivatives are at the forefront of the current standard chemotherapeutic regimen for active tuberculosis; they act by inhibiting the transcription activity of prokaryotic RNA polymerase. Rifampicin is believed to interact with the subunit of RNA polymerase. However, it has been observed that protein–protein interactions with RNA polymerase core enzyme lead to its reduced susceptibility to rifampicin. This mechanism became more diversified with the discovery of RbpA, a novel RNA polymerase-binding protein, in that could mitigate the effect of rifampicin on RNA polymerase activity. MsRbpA is a homologue of RbpA in On deciphering the role of MsRbpA in we found that it interacts with RNA polymerase and increases the rifampicin tolerance levels, both and It interacts with the subunit of RNA polymerase. However, it was found to be incapable of rescuing rifampicin-resistant RNA polymerases in the presence of rifampicin at the respective IC.

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2010-03-01
2020-02-22
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