The cell wall galactomannan antigen from and contains -1,6-linked linear galactofuranosyl residues and its detection has diagnostic potential Free

Abstract

Lipophilic yeasts of the genus are associated with several skin diseases, such as pityriasis versicolor, folliculitis, seborrhoeic dermatitis and atopic dermatitis, and are also increasingly associated with catheter-related fungaemia. The cell wall components of pathogenic micro-organisms behave as an antigen and/or ligand of the innate immune response. Live cells of and did not react with an anti--1,2-mannoside antibody. However, they showed a strong hydrophobicity and reactivity with an anti--1,3-glucan antibody compared to those of . The cell wall polysaccharides of and were isolated and their structures analysed by H and C NMR experiments. Both polysaccharides were shown to be -1,6-linked linear galactofuranosyl polymers with a small amount of mannan. The presence of galactomannan on cells of species has not been described previously. The galactomannan did not react with an anti- monoclonal antibody which has specificity for -1,5-linked galactofuranosyl residues. An anti- antibody strongly reacted with the galactomannans of and but did not react with the galactomannans of , or The characteristics of the anti- antibody suggest that there is potential for diagnosis of infections by antigen detection.

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2009-10-01
2024-03-28
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