1887

Abstract

causes equine ‘strangles’. Hyaluronate lyases, which degrade connective tissue hyaluronan and chondroitins, are thought to facilitate streptococcal invasion of the host. However, prophage-encoded hyaluronate lyases are hyaluronan-specific and are thought to be primarily involved in the degradation of the hyaluronan capsule of streptococci during bacteriophage infection. To understand the role of prophage-encoded hyaluronate lyases further, we have biochemically characterized such a hyaluronate lyase, SEQ2045 from , and have shown that it is produced during equine infection. Prophage-encoded hyaluronan-specific hyaluronate lyases may therefore play a more direct role in disease pathogenesis than previously thought.

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2009-02-01
2020-01-21
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vol. , part 2, pp. 443 - 449

12 % (w/v) SDS-polyacrylamide gel of the 42 kDa N-terminally hexahistidine-tagged protein SEQ2045 [ PDF] (137 kb)



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