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Graphical Abstract

 Graphical Abstract 

undergoing the spore-to-spore life cycle in liquid culture makes it a versatile model organism for generating key insights into the regulatory networks, cell biology and development of this genus.

 

 

Abstract

bacteria are renowned for their multicellular lifestyle and production of bioactive molecules (natural products) with important applications in medicine, agriculture and industry. Studies of several species have provided a foundational understanding of their biology and metabolism. However, investigating the spatiotemporal processes governing the morphogenesis and development of these remarkable bacteria has been technically challenging due to their complex life cycle. The adoption of as a new experimental model species has overcome these limitations and opened the door to fully explore the regulation and cell biology of development. A key advantage of is its ability to complete its entire life cycle in liquid culture, facilitating the effective use of genome-wide analysis techniques and advanced cell biology approaches. This has provided significant new insights into the regulatory networks and molecular mechanisms underlying growth, division, developmental transitions and genome organization.

Funding
This study was supported by the:
  • Biotechnology and Biological Sciences Research Council (Award BB/X01097X/1)
    • Principle Award Recipient: NotApplicable
  • Royal Society (Award URF\R\231009)
    • Principle Award Recipient: SusanSchlimpert
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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/content/journal/micro/10.1099/mic.0.001541
2025-03-13
2025-04-25
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