Skip to content
1887

Microbiology Society logo Microbiology

Volume 171, Issue 1

Microbe Profile: Typhimurium: the master of the art of adaptation Open Access

This article is part of the Microbe Profiles collection

Graphical Abstract

 Graphical abstract 

Visual overview of the pathogenesis, virulence characteristics and taxonomic classification of Typhimurium. Left panel: key characteristics of Typhimurium. Right panel: taxonomy of , subspecies and serovars. iNTS: invasive non-typhoidal ; Mφ: macrophage; DC: dendritic cell; SPIs: pathogenicity islands. Perez-Sepulveda & Hinton Microbe Profile: Typhimurium.

 

 

Abstract

Typhimurium is a major serovar that is found globally. It is responsible for outbreaks of self-limiting gastroenteritis that are broadly linked to the industrialization of food production. . Typhimurium is a pathogen with a broad host range and remarkable metabolic versatility. The ∼5 Mb genome includes the pSLT virulence plasmid and has a characteristic prophage repertoire. The major virulence determinants are encoded by a variety of pathogenicity islands. Emerging multidrug-resistant lineages of epidemics of . Typhimurium are currently causing bloodstream infections in sub-Saharan Africa. The versatility and adaptability of . Typhimurium pose an important public health challenge.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): genome , pathogen , Salmonella and virulence
Funding
This study was supported by the:
  • Wellcome Trust (Award 222528/Z/21/Z)
    • Principle Award Recipient: JayC. D. Hinton
© 2025 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
Loading

Article metrics loading...

/content/journal/micro/10.1099/mic.0.001521
2025-01-09
2025-02-13
Loading full text...

Full text loading...

/deliver/fulltext/micro/171/1/mic001521.html?itemId=/content/journal/micro/10.1099/mic.0.001521&mimeType=html&fmt=ahah

References

  1. Gutnick D, Calvo JM, Klopotowski T, Ames BN. Compounds which serve as the sole source of carbon or nitrogen for Salmonella typhimurium LT-2. J Bacteriol 1969; 100:215–219 [View Article] [PubMed]
     [Google Scholar]
  2. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P et al. Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature 2001; 413:852–856 [View Article] [PubMed]
     [Google Scholar]
  3. Achtman M, Zhou Z, Charlesworth J, Baxter L. EnteroBase: hierarchical clustering of 100 000s of bacterial genomes into species/subspecies and populations. Phil Trans R Soc B 2022; 377:20210240 [View Article]
     [Google Scholar]
  4. Branchu P, Bawn M, Kingsley RA. Genome variation and molecular epidemiology of Salmonella enterica serovar Typhimurium pathovariants. Infect Immun 2018; 86:e00079-18 [View Article] [PubMed]
     [Google Scholar]
  5. Pulford CV, Perez-Sepulveda BM, Canals R, Bevington JA, Bengtsson RJ et al. Stepwise evolution of Salmonella typhimurium ST313 causing bloodstream infection in Africa. Nat Microbiol 2021; 6:327–338 [View Article] [PubMed]
     [Google Scholar]
  6. Wagner C, Hensel M. Adhesive Mechanisms of Salmonella enterica. In Linke D, Goldman A. eds Bacterial Adhesion: Chemistry, Biology and Physics Dordrecht: Springer Netherlands; pp 17–34
     [Google Scholar]
  7. Tsolis RM, Xavier MN, Santos RL, Bäumler AJ. How to become a top model: impact of animal experimentation on human Salmonella disease research. Infect Immun 2011; 79:1806–1814 [View Article] [PubMed]
     [Google Scholar]
  8. Crump JA, Nyirenda TS, Kalonji LM, Phoba M-F, Tack B et al. Nontyphoidal Salmonella invasive disease: challenges and solutions. Open Forum Infect Dis 2023; 10:S32–S37 [View Article] [PubMed]
     [Google Scholar]
  9. Kröger C, Colgan A, Srikumar S, Händler K, Sivasankaran SK et al. An infection-relevant transcriptomic compendium for Salmonella enterica Serovar Typhimurium. Cell Host Microbe 2013; 14:683–695 [View Article] [PubMed]
     [Google Scholar]
  10. Taylor SJ, Winter SE. Salmonella finds a way: metabolic versatility of Salmonella enterica serovar Typhimurium in diverse host environments. PLoS Pathog 2020; 16:e1008540 [View Article] [PubMed]
     [Google Scholar]
/content/journal/micro/10.1099/mic.0.001521
Loading

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error