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Microbiology Society logo Microbiology

Volume 171, Issue 1

Microbe Profile: Typhimurium: the master of the art of adaptation Open Access

This article is part of the Microbe Profiles collection

Graphical Abstract

 Graphical abstract 

Visual overview of the pathogenesis, virulence characteristics and taxonomic classification of Typhimurium. Left panel: key characteristics of Typhimurium. Right panel: taxonomy of , subspecies and serovars. iNTS: invasive non-typhoidal ; Mφ: macrophage; DC: dendritic cell; SPIs: pathogenicity islands. Perez-Sepulveda & Hinton Microbe Profile: Typhimurium.

 

 

Abstract

Typhimurium is a major serovar that is found globally. It is responsible for outbreaks of self-limiting gastroenteritis that are broadly linked to the industrialization of food production. . Typhimurium is a pathogen with a broad host range and remarkable metabolic versatility. The ∼5 Mb genome includes the pSLT virulence plasmid and has a characteristic prophage repertoire. The major virulence determinants are encoded by a variety of pathogenicity islands. Emerging multidrug-resistant lineages of epidemics of . Typhimurium are currently causing bloodstream infections in sub-Saharan Africa. The versatility and adaptability of . Typhimurium pose an important public health challenge.

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  • Accepted:
  • Published Online:
Keyword(s): genome , pathogen , Salmonella and virulence
Funding
This study was supported by the:
  • Wellcome Trust (Award 222528/Z/21/Z)
    • Principle Award Recipient: JayC. D. Hinton
© 2025 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2025-01-09
2025-01-15
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