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Volume 170, Issue 11

Microbe Profile: – a master of deception Open Access

This article is part of the Microbe Profiles collection.

Graphical Abstract

 Graphical abstract 

, an opportunistic fungal pathogen. (a) Unable to form hyphae, relies on tissue disruption to invade and disseminate host. (b) Calcofluor-white cells, 60X objective. (c) Colony morphology on YPD.

 

 

Abstract

is a fungal microbe associated with multiple vertebrate microbiomes and their terrestrial environments. In humans, the species has emerged as an opportunistic pathogen that now ranks as the second-leading cause of candidiasis in Europe and North America (Beardsley . 2024, 62). People at highest risk of infection include the elderly, immunocompromised individuals and/or long-term residents of hospital and assisted-living facilities. is intrinsically drug-resistant, metabolically versatile and able to avoid detection by the immune system. Analyses of its 12.3 Mb genome indicate a stable pangenome Marcet-Houben . ( 2022, 20) and phylogenetic affinity with . Recent phylogenetic analyses suggest reclassifying as Lakashima and Sugita ( 2022, 63: 119-132).

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Keyword(s): Candida glabrata , candidiasis , opportunistic pathogen and yeast
Funding
This study was supported by the:
  • Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Award 1R01AI 136992-01A1)
    • Principle Award Recipient: GavinSherlock
© 2024 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2024-11-26
2024-12-08
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