1887

Abstract

Synergistic interactions between chemical inhibitors, whilst informative, can be difficult to interpret, as chemical inhibitors can often have multiple targets, many of which can be unknown. Here, using multiplexed transcriptional repression, we have validated that the simultaneous repression of glutamate racemase and alanine racemase has a synergistic interaction in . This confirms prior observations from chemical interaction studies and highlights the potential of targeting multiple enzymes involved in mycobacterial cell wall synthesis.

Funding
This study was supported by the:
  • Maurice Wilkins Centre for Molecular Biodiscovery
    • Principle Award Recipient: KurtLamont Krause
  • Sir Charles Hercus Health Research Fellowship (Award ID 22/156)
    • Principle Award Recipient: MatthewB McNeil
  • Health Research Council of New Zealand (Award Grant IDs 19/259, 23/396)
    • Principle Award Recipient: KurtLamont Krause
  • Maurice Wilkins Centre for Molecular Biodiscovery
    • Principle Award Recipient: GregoryM Cook
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2024-08-08
2024-11-05
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