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Abstract

The stringent response is a conserved bacterial stress response that allows bacteria to alter their activity and survive under nutrient-limiting conditions. Activation of the stringent response is characterized by the production of intracellular signalling molecules, collectively termed (p)ppGpp, which interact with multiple targets inside bacterial cells. Together, these interactions induce a slow growth phenotype to aid bacterial survival by altering the transcriptomic profile of the cell, inhibiting ribosome biosynthesis and targeting enzymes involved in other key metabolic processes.

Keyword(s): ppGpp , stress and stringent response
Funding
This study was supported by the:
  • Biotechnology and Biological Sciences Research Council (Award BB/T007222/1)
    • Principle Award Recipient: OrestisSavva
  • Lister Institute of Preventive Medicine
    • Principle Award Recipient: RebeccaCorrigan
  • Wellcome Trust (Award 104110/Z/14/A)
    • Principle Award Recipient: RebeccaCorrigan
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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/content/journal/micro/10.1099/mic.0.001483
2024-07-30
2024-10-03
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