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Volume 169, Issue 3

Regulation of phosphate starvation-specific responses in Open Access

Abstract

Toxic agents added into the medium of rapidly growing induce specific stress responses through the activation of specialized transcription factors. Each transcription factor and downstream regulon (e.g. SoxR) are linked to a unique stress (e.g. superoxide stress). Cells starved of phosphate induce several specific stress regulons during the transition to stationary phase when the growth rate is steadily declining. Whereas the regulatory cascades leading to the expression of specific stress regulons are well known in rapidly growing cells stressed by toxic products, they are poorly understood in cells starved of phosphate. The intent of this review is to both describe the unique mechanisms of activation of specialized transcription factors and discuss signalling cascades leading to the induction of specific stress regulons in phosphate-starved cells. Finally, I discuss unique defence mechanisms that could be induced in cells starved of ammonium and glucose.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): CpxR , Kdp , LexA , PtsN , RpoE and SoxR
© 2023 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2023-03-27
2024-04-23
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Regulation of phosphate starvation-specific responses in Escherichia coli
Microbiology 169, 001312 (2023); https://doi.org/10.1099/mic.0.001312
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