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Abstract

The type VI secretion system (T6SS) is a molecular puncturing device that enables Gram-negative bacteria to kill competitors, manipulate host cells and take up nutrients. Who would want to miss such superpowers? Indeed, many studies show how widespread the secretion apparatus is among microbes. However, it is becoming evident that, on multiple taxonomic levels, from phyla to species and strains, some bacteria lack a T6SS. Here, we review who does and does not have a type VI secretion apparatus and speculate on the dynamic process of gaining and losing the secretion system to better understand its spread and distribution across the microbial world.

Funding
This study was supported by the:
  • Max-Planck-Gesellschaft (Award IMPRS EvolBio)
    • Principle Award Recipient: RahulUnni
  • Bundesministerium für Bildung und Forschung (Award 01KI2020)
    • Principle Award Recipient: DanielUnterweger
  • Deutsche Forschungsgemeinschaft (Award CRC1182 B4)
    • Principle Award Recipient: DanielUnterweger
  • Deutsche Forschungsgemeinschaft (Award Manuscript_Revision.docx)
    • Principle Award Recipient: AndreasDiepold
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. The Microbiology Society waived the open access fees for this article.
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2022-04-25
2022-08-13
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