1887

Abstract

is an environmental bacterium that parasitizes aquatic protozoa and uses the same processes to infect humans. The facultative intracellular pathogen causes a life-threatening pneumonia with possible systemic complications. The co-evolution with protozoa is reflected in an armoury of bacterial effectors, and many of these type IV-secreted proteins have likely been acquired by interdomain horizontal gene transfer (HGT) from hosts. The unique features of are the largest bacterial effector repertoire known to date, subversion of virtually all eukaryotic signalling pathways and acquisition of eukaryotic enzyme activities used to manipulate the host cell to the pathogen’s advantage.

Funding
This study was supported by the:
  • Fondation pour la Recherche Médicale (Award EQU201903007847)
    • Principle Award Recipient: CarmenBuchrieser
  • Fondation pour la Recherche Médicale
    • Principle Award Recipient: HubertHilbi
  • Swiss National Science Foundation (Award 31003A_175557 and 310030_200706)
    • Principle Award Recipient: HilbiHubert
  • Agence Nationale de la Recherche (Award ANR-10-LABX-62-IBEID)
    • Principle Award Recipient: CarmenBuchrieser
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/content/journal/micro/10.1099/mic.0.001142
2022-03-01
2022-07-06
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References

  1. Cazalet C, Rusniok C, Brüggemann H, Zidane N, Magnier A et al. Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nat Genet 2004; 36:1165–1173 [View Article] [PubMed]
    [Google Scholar]
  2. Chien M, Morozova I, Shi S, Sheng H, Chen J et al. The genomic sequence of the accidental pathogen Legionella pneumophila. Science 2004; 305:1966–1968 [View Article] [PubMed]
    [Google Scholar]
  3. McDade JE, Shepard CC, Fraser DW, Tsai TR, Redus MA et al. Legionnaires’ disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N Engl J Med 1977; 297:1197–1203 [View Article] [PubMed]
    [Google Scholar]
  4. Gomez-Valero L, Rusniok C, Carson D, Mondino S, Pérez-Cobas AE et al. More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells. Proc Natl Acad Sci U S A 2019; 116:2265–2273 [View Article] [PubMed]
    [Google Scholar]
  5. Park JM, Ghosh S, O’Connor TJ. Combinatorial selection in amoebal hosts drives the evolution of the human pathogen Legionella pneumophila. Nat Microbiol 2020; 5:599–609 [View Article] [PubMed]
    [Google Scholar]
  6. Ensminger AW. Legionella pneumophila, armed to the hilt: justifying the largest arsenal of effectors in the bacterial world. Curr Opin Microbiol 2016; 29:74–80 [View Article] [PubMed]
    [Google Scholar]
  7. Qiu J, Luo ZQ. Legionella and Coxiella effectors: strength in diversity and activity. Nat Rev Microbiol 2017; 15:591–605 [View Article] [PubMed]
    [Google Scholar]
  8. Kubori T, Shinzawa N, Kanuka H, Nagai H. Legionella metaeffector exploits host proteasome to temporally regulate cognate effector. PLoS Pathog 2010; 6:12 [View Article] [PubMed]
    [Google Scholar]
  9. Weber SS, Ragaz C, Reus K, Nyfeler Y, Hilbi H. Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. PLoS Pathog 2006; 2:e46 [View Article] [PubMed]
    [Google Scholar]
  10. Striednig B, Hilbi H. Bacterial quorum sensing and phenotypic heterogeneity: how the collective shapes the individual. Trends Microbiol 2021 [View Article] [PubMed]
    [Google Scholar]
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