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Volume 167, Issue 12

The methylation-independent mismatch repair machinery in Open Access

Abstract

Over the last 70 years, we’ve all gotten used to an -centric view of the microbial world. However, genomics, as well as the development of improved tools for genetic manipulation in other species, is showing us that other bugs do things differently, and that we cannot simply extrapolate from to everything else. A particularly good example of this is encountered when considering the mechanism(s) involved in DNA mismatch repair by the opportunistic human pathogen, (PA). This is a particularly relevant phenotype to examine in PA, since defects in the mismatch repair (MMR) machinery often give rise to the property of hypermutability. This, in turn, is linked with the vertical acquisition of important pathoadaptive traits in the organism, such as antimicrobial resistance. But it turns out that PA lacks some key genes associated with MMR in , and a closer inspection of what is known (or can be inferred) about the MMR enzymology reveals profound differences compared with other, well-characterized organisms. Here, we review these differences and comment on their biological implications.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): hypermutation , mismatch repair , MutL , MutS and Pseudomonas aeruginosa
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2021-12-09
2024-09-17
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/content/journal/micro/10.1099/mic.0.001120
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The methylation-independent mismatch repair machinery in Pseudomonas aeruginosa
Microbiology 167, 001120 (2021); https://doi.org/10.1099/mic.0.001120
/content/journal/micro/10.1099/mic.0.001120
/content/journal/micro/10.1099/mic.0.001120
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