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Volume 167, Issue 9

Integrating perspectives in actinomycete research: an ActinoBase review of 2020–21 Open Access

Abstract

Last year ActinoBase, a Wiki-style initiative supported by the UK Microbiology Society, published a review highlighting the research of particular interest to the actinomycete community. Here, we present the second ActinoBase review showcasing selected reports published in 2020 and early 2021, integrating perspectives in the actinomycete field. Actinomycetes are well-known for their unsurpassed ability to produce specialised metabolites, of which many are used as therapeutic agents with antibacterial, antifungal, or immunosuppressive activities. Much research is carried out to understand the purpose of these metabolites in the environment, either within communities or in host interactions. Moreover, many efforts have been placed in developing computational tools to handle big data, simplify experimental design, and find new biosynthetic gene cluster prioritisation strategies. Alongside, synthetic biology has provided advances in tools to elucidate the biosynthesis of these metabolites. Additionally, there are still mysteries to be uncovered in understanding the fundamentals of filamentous actinomycetes' developmental cycle and regulation of their metabolism. This review focuses on research using integrative methodologies and approaches to understand the bigger picture of actinomycete biology, covering four research areas: ) technology and methodology; ) specialised metabolites; ) development and regulation; and ) ecology and host interactions.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Actinobacteria , ActinoBase , development , integrating perspectives , methodology , microbial ecology , natural products , regulation , specialised metabolites and Streptomyces
Funding
This study was supported by the:
  • Biotechnology and Biological Sciences Research Council (Award BB/S016651/1)
    • Principle Award Recipient: Katharina SchnieteJana
  • H2020 Marie Skłodowska-Curie Actions (Award 765147)
    • Principle Award Recipient: VindKristiina
  • Programa de Innovacion y Capital Humano para la Competitividad (PINN) (Award 2-1-4-17-1-037)
    • Principle Award Recipient: ParraJonathan
  • National Center for Genetic Engineering and Biotechnology
    • Principle Award Recipient: KruasuwanWorarat
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (Award 143700/2018-9)
    • Principle Award Recipient: F PereiraCamila
  • Fapesp (Award 2018/17502-2)
    • Principle Award Recipient: F PereiraCamila
  • Fondo Nacional de Desarrollo Científico y Tecnológico (Award 3180399)
    • Principle Award Recipient: UndabarrenaAgustina
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2021-09-13
2024-04-24
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Integrating perspectives in actinomycete research: an ActinoBase review of 2020–21
Microbiology 167, 001084 (2021); https://doi.org/10.1099/mic.0.001084
/content/journal/micro/10.1099/mic.0.001084
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