1887

Abstract

Microorganisms encounter toxicities inside the host. Many pathogens exist as subpopulations to maximize survivability. Subpopulations of include antibiotic-tolerant small colony variants (SCVs). These mutants often emerge following antibiotic treatment but can be present in infections prior to antibiotic exposure. We hypothesize that haem toxicity in the host selects for respiration-deficient SCVs in the absence of antibiotics. We demonstrate that some but not all respiration-deficient SCV phenotypes are more protective than the haem detoxification system against transient haem exposure, indicating that haem toxicity in the host may contribute to the dominance of menaquinone-deficient and haem-deficient SCVs prior to antibiotic treatment.

Funding
This study was supported by the:
  • National Institute of General Medical Sciences (Award R15GM128072)
    • Principle Award Recipient: WakemanCatherine
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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/content/journal/micro/10.1099/mic.0.001044
2021-04-19
2021-10-28
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