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Volume 167, Issue 3

Microbe Profile: : model system for development, chemotaxis and biomedical research Open Access

This article is part of the Microbe Profiles collection.

Abstract

The social amoeba is a versatile organism that is unusual in alternating between single-celled and multi-celled forms. It possesses highly-developed systems for cell motility and chemotaxis, phagocytosis, and developmental pattern formation. As a soil amoeba growing on microorganisms, it is exposed to many potential pathogens; it thus provides fruitful ways of investigating host-pathogen interactions and is emerging as an influential model for biomedical research.

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  • Accepted:
  • Published Online:
Keyword(s): Biomedical model , Chemotaxis , Development , Dictyostelium discoideum and Social conflict
Funding
This study was supported by the:
  • Medical Research Council (Award MR/P028284/1)
    • Principle Award Recipient: CatherinePears
  • National Centre for the Replacement, Refinement and Reduction of Animals in Research (Award CrackIt Solution)
    • Principle Award Recipient: CatherinePears
  • National Centre for the Replacement, Refinement and Reduction of Animals in Research (Award NC/M000834/1)
    • Principle Award Recipient: CatherinePears
© 2021 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2021-03-01
2024-04-25
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References

  1. Kessin RH. Dictyostelium: Evolution, Cell Biology, and the Development of Multicellularity Cambridge: Cambridge University Press; 2001
     [Google Scholar]
  2. Eichinger L, Pachebat JA, Glöckner G, Rajandream M-A, Sucgang R et al. The genome of the social amoeba Dictyostelium discoideum . Nature 2005; 435:43–57 [View Article][PubMed]
     [Google Scholar]
  3. Kawabe Y, Du Q, Schilde C, Schaap P. Evolution of multicellularity in Dictyostelia. Int J Dev Biol 2019; 63:359–369 [View Article][PubMed]
     [Google Scholar]
  4. Loomis WF. Genetic control of morphogenesis in Dictyostelium . Dev Biol 2015; 402:146–161 [View Article][PubMed]
     [Google Scholar]
  5. Medina JM, Shreenidhi PM, Larsen TJ, Queller DC, Strassmann JE. Cooperation and conflict in the social amoeba Dictyostelium discoideum . Int J Dev Biol 2019; 63:371–382 [View Article][PubMed]
     [Google Scholar]
  6. Pal DS, Li X, Banerjee T, Miao Y, Devreotes PN. The excitable signal transduction networks: movers and shapers of eukaryotic cell migration. Int J Dev Biol 2019; 63:407–416 [View Article][PubMed]
     [Google Scholar]
  7. Vines JH, King JS. The endocytic pathways of Dictyostelium discoideum . Int J Dev Biol 2019; 63:461–471 [View Article][PubMed]
     [Google Scholar]
  8. Dunn JD, Bosmani C, Barisch C, Raykov L, Lefrançois LH et al. Eat prey, live: Dictyostelium discoideum as a model for cell-autonomous defenses. Front Immunol 2017; 8:8 [View Article][PubMed]
     [Google Scholar]
  9. Chen G, Zhuchenko O, Kuspa A. Immune-like phagocyte activity in the social amoeba. Science 2007; 317:678–681 [View Article][PubMed]
     [Google Scholar]
  10. Schaf J, Damstra-Oddy J, Williams RSB. Dictyostelium discoideum as a pharmacological model system to study the mechanisms of medicinal drugs and natural products. Int J Dev Biol 2019; 63:541–550 [View Article][PubMed]
     [Google Scholar]
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