RT Journal Article SR Electronic(1) A1 Li, Yunlong A1 Sharma, Manjuli R. A1 Koripella, Ravi K. A1 Banavali, Nilesh K. A1 Agrawal, Rajendra K. A1 Ojha, Anil K.YR 2021 T1 Ribosome hibernation: a new molecular framework for targeting nonreplicating persisters of mycobacteria JF Microbiology, VO 167 IS 2 OP SP 001035 DO https://doi.org/10.1099/mic.0.001035 PB Microbiology Society, SN 1465-2080, AB Treatment of tuberculosis requires a multi-drug regimen administered for at least 6 months. The long-term chemotherapy is attributed in part to a minor subpopulation of nonreplicating Mycobacterium tuberculosis cells that exhibit phenotypic tolerance to antibiotics. The origins of these cells in infected hosts remain unclear. Here we discuss some recent evidence supporting the hypothesis that hibernation of ribosomes in M. tuberculosis, induced by zinc starvation, could be one of the primary mechanisms driving the development of nonreplicating persisters in hosts. We further analyse inconsistencies in previously reported studies to clarify the molecular principles underlying mycobacterial ribosome hibernation., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.001035