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Volume 166, Issue 7

Microbe Profile: : a methanol devouring biotech yeast formerly known as Free

This article is part of the Microbe Profiles collection.

Abstract

Methylotrophic yeasts of the genus are abundantly found in tree exudates. Their ability to utilize methanol as carbon and energy source relies on an assimilation pathway localized in largely expanded peroxisomes, and a cytosolic methanol dissimilation pathway. Other substrates like glucose or glycerol are readily utilized as well. yeasts usually grow as haploid cells and are secondary homothallic as they can switch mating type. Upon mating diploid cells sporulate readily, forming asci with four haploid spores. Their ability to secrete high amounts of heterologous proteins made them interesting for biotechnology, which expands today also to other products of primary and secondary metabolism.

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Keyword(s): budding yeast , Komagataella , methylotroph , protein production and yeast biotechnology
Funding
This study was supported by the:
  • Austrian Science Fund (Award W1224)
    • Principle Award Recipient: Diethard Mattanovich
  • Christian Doppler Forschungsgesellschaft
    • Principle Award Recipient: Brigitte Gasser
  • Österreichische Forschungsförderungsgesellschaft (AT) (Award acib)
    • Principle Award Recipient: Diethard Mattanovich
© 2020 The Authors
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/content/journal/micro/10.1099/mic.0.000958
2020-07-28
2024-04-16
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