Microbe Profile: : model organism for cellular development, and industrial workhorse Open Access

Abstract

is the best studied model organism of the Gram-positive lineage. It is naturally transformable and has an extremely powerful genetic toolbox. It is fast growing and easy to cultivate. It is an important industrial organism, being proficient at secreting proteins and making small fine chemicals, as well as acting as a plant growth promoter. It has been an important model system for studying biofilms. Finally, it makes endospores, which have provided an exceptionally fruitful system for studying various central problems of cellular development, including the generation of asymmetry, cell fate determination and morphogenesis.

Funding
This study was supported by the:
  • H2020 European Research Council (Award 670980)
    • Principle Award Recipient: Jeffery Errington
  • Wellcome Trust (Award 209500)
    • Principle Award Recipient: Jeffery Errington
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/content/journal/micro/10.1099/mic.0.000922
2020-05-11
2024-03-28
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References

  1. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G et al. The complete genome sequence of the Gram-positive bacterium Bacillus subtilis. Nature 1997; 390:249–256 [View Article][PubMed][PubMed]
    [Google Scholar]
  2. Borriss R, Danchin A, Harwood CR, Médigue C, Rocha EPC et al. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Microb Biotechnol 2018; 11:3–17 [View Article]
    [Google Scholar]
  3. Nicolas P, Mäder U, Dervyn E, Rochat T, Leduc A et al. Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis. Science 2012; 335:1103–1106 [View Article][PubMed][PubMed]
    [Google Scholar]
  4. Koo B-M, Kritikos G, Farelli JD, Todor H, Tong K et al. Construction and analysis of two genome-scale deletion libraries for Bacillus subtilis . Cell Syst 2017; 4:291–305 [View Article]
    [Google Scholar]
  5. Cohn F. Untersuchungen über Bacterien. Beitrage zur Biologie der Pflanzen Heft 2 1872; 1:127–224
    [Google Scholar]
  6. Soule MH. Identity of Bacillus subtilis, Cohn 1872. J Infect Dis 1932; 51:191–215 [View Article]
    [Google Scholar]
  7. Logan NA, de Vos P. Genus I. Bacillus Cohn 1872. Bergey’s Manual of Systematic Bacteriology Second Edition, Volume 3, The Firmicutes 2009 pp 21–128
    [Google Scholar]
  8. Zeigler DR. The genome sequence of Bacillus subtilis subsp. spizizenii W23: insights into speciation within the B. subtilis complex and into the history of B. subtilis genetics. Microbiology 2011; 157:2033–2041 [View Article]
    [Google Scholar]
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