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Volume 166, Issue 6

Microbial gas vesicles as nanotechnology tools: exploiting intracellular organelles for translational utility in biotechnology, medicine and the environment Open Access

Abstract

A range of bacteria and archaea produce gas vesicles as a means to facilitate flotation. These gas vesicles have been purified from a number of species and their applications in biotechnology and medicine are reviewed here. sp. NRC-1 gas vesicles have been engineered to display antigens from eukaryotic, bacterial and viral pathogens. The ability of these recombinant nanoparticles to generate an immune response has been quantified both and . These gas vesicles, along with those purified from and , have been developed as an acoustic reporter system. This system utilizes the ability of gas vesicles to retain gas within a stable, rigid structure to produce contrast upon exposure to ultrasound. The susceptibility of gas vesicles to collapse when exposed to excess pressure has also been proposed as a biocontrol mechanism to disperse cyanobacterial blooms, providing an environmental function for these structures.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): cyanobacterial blooms , gas vesicles , magnetic resonance imaging , nanotechnology and recombinant vaccines
Funding
This study was supported by the:
  • Biotechnology and Biological Sciences Research Council (Award BB/K001833/1 and BB/N008081/1)
    • Principle Award Recipient: George P. C. Salmond
© 2020 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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Microbial gas vesicles as nanotechnology tools: exploiting intracellular organelles for translational utility in biotechnology, medicine and the environment
Microbiology 166, 501 (2020); https://doi.org/10.1099/mic.0.000912
/content/journal/micro/10.1099/mic.0.000912
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