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Volume 166, Issue 5

The need to unravel the twisted nature of the sensu lato complex across Europe Free

Abstract

Lyme borreliosis is a vector-borne infection caused by bacteria under the sensu lato complex, both in Europe and North America. Differential gene expression at different times throughout its infectious cycle allows the spirochete to survive very diverse environments within different mammalian hosts as well as the tick vector. To date, the vast majority of data about spirochetal proteins and their functions are from genetic studies carried out on North American strains of a single species, i.e. . The whole-genome sequences recently obtained for several European species/strains make it feasible to adapt and use genetic techniques to study inherent differences between them. This review highlights the crucial need to undertake independent studies of genospecies within Europe, given their varying genetic content and pathogenic potential, and differences in clinical manifestation.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): Borrelia diversity , Europe vs North America , genetic manipulations , Lyme borreliosis and tick
Funding
This study was supported by the:
  • Grantová Agentura České Republiky (Award 17-21244S)
    • Principle Award Recipient: Ryan Oliver Marino Rego
© 2020 The Authors
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2020-03-03
2024-04-25
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The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe
Microbiology 166, 428 (2020); https://doi.org/10.1099/mic.0.000899
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