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Volume 166, Issue 6

Transient enhanced cell division by blocking DNA synthesis in Open Access

Abstract

Duplication of the bacterial nucleoid is necessary for cell division hence specific arrest of DNA replication inhibits divisions culminating in filamentation, nucleoid dispersion and appearance of a-nucleated cells. It is demonstrated here that during the first 10 min however, enhanced residual divisions: the proportion of constricted cells doubled (to 40%), nucleoids contracted and cells remodelled dimensions: length decreased and width increased. The preliminary data provides further support to the existence of temporal and spatial couplings between the nucleoid/replisome and the sacculus/divisome, and is consistent with the idea that bacillary bacteria modulate width during the division process exclusively.

  • Received:
  • Accepted:
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Keyword(s): cell division and dimensions , DNA replication and nucleoid morphology
Funding
This study was supported by the:
  • United States - Israel Binational Science Foundation (Award 2017004)
    • Principle Award Recipient: Professor Arieh Zaritsky
© 2020 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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2020-03-02
2024-04-23
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Transient enhanced cell division by blocking DNA synthesis in Escherichia coli
Microbiology 166, 516 (2020); https://doi.org/10.1099/mic.0.000888
/content/journal/micro/10.1099/mic.0.000888
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