1887

Microbiology

Volume 165, Issue 8

Resistance is not futile: bacterial ‘innate’ and CRISPR-Cas ‘adaptive’ immune systems Free

Abstract

Bacteria are under a constant pressure from their viruses (phages) and other mobile genetic elements. They protect themselves through a range of defence strategies, which can be broadly classified as ‘innate’ and ‘adaptive’. The bacterial innate immune systems include defences provided by restriction modification and abortive infection, among others. Bacterial adaptive immunity is elicited by a diverse range of CRISPR-Cas systems. Here, I discuss our research on both innate and adaptive phage resistance mechanisms and some of the evasion strategies employed by phages.

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Keyword(s): abortive infection , bacteriophages , CRISPR-Cas , phage resistance and toxin-antitoxin
© 2019 The Authors
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2019-08-01
2021-03-04
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Resistance is not futile: bacterial ‘innate’ and CRISPR-Cas ‘adaptive’ immune systems
Microbiology 165, 834 (2019); https://doi.org/10.1099/mic.0.000802
/content/journal/micro/10.1099/mic.0.000802
/content/journal/micro/10.1099/mic.0.000802
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