@article{mbs:/content/journal/micro/10.1099/mic.0.000779, author = "Portugal, Rebecca and Shao, Nana and Whitman, William B. and Allen, Kylie D. and White, Robert H.", title = "Identification and biosynthesis of 2-(1H-imidazol-5-yl) ethan-1-ol (histaminol) in methanogenic archaea", journal= "Microbiology", year = "2019", volume = "165", number = "4", pages = "455-462", doi = "https://doi.org/10.1099/mic.0.000779", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/mic.0.000779", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", keywords = "siderophores", keywords = "methanogens", keywords = "Histaminol", abstract = "Histaminol is a relatively rare metabolite most commonly resulting from histidine metabolism. Here we describe histaminol production and secretion into the culture broth by the methanogen Methanococcus maripaludis S2 as well as a number of other methanogens. This work is the first identification of this compound as a natural product in methanogens. Its biosynthesis from histidine was confirmed by the incorporation of 2H3-histidine into histaminol by growing cells of M. maripaludis S2. Possible functions of this molecule could be cell signaling as observed with histamine in eukaryotes or uptake of metal ions.", }