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Volume 165, Issue 2

Editor's Choice The Streptococcos suis sortases SrtB and SrtF are essential for disease in pigs Open Access

Abstract

The porcine pathogen Streptococcus suis colonizes the upper respiratory tracts of pigs, potentially causing septicaemia, meningitis and death, thus placing a severe burden on the agricultural industry worldwide. It is also a zoonotic pathogen that is known to cause systemic infections and meningitis in humans. Understanding how S. suis colonizes and interacts with its hosts is relevant for future strategies of drug and vaccine development. As with other Gram-positive bacteria, S. suis utilizes enzymes known as sortases to attach specific proteins bearing cell wall sorting signals to its surface, where they can play a role in host–pathogen interactions. The surface proteins of bacteria are often important in adhesion to and invasion of host cells. In this study, markerless in-frame deletion mutants of the housekeeping sortase srtA and the two pilus-associated sortases, srtB and srtF, were generated and their importance in S. suis infections was investigated. We found that all three of these sortases are essential to disease in pigs, concluding that their cognate-sorted proteins may also be useful in protecting pigs against infection.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): pili , Sortase , Streptococcus suis and type C sortases
© 2019 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2018-12-13
2024-04-23
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The Streptococcos suis sortases SrtB and SrtF are essential for disease in pigs
Microbiology 165, 163 (2019); https://doi.org/10.1099/mic.0.000752
/content/journal/micro/10.1099/mic.0.000752
/content/journal/micro/10.1099/mic.0.000752
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