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Volume 164, Issue 6

Microbe Profile: – an old foe always ready to seize opportunity Open Access

This article is part of the Microbe Profiles collection.

Abstract

is a globally important Gram-positive aerobic Actinobacterium capable of causing the toxin-mediated disease, diphtheria. Diphtheria was a major cause of childhood mortality prior to the introduction of the toxoid vaccine, yet it is capable of rapid resurgence following the breakdown of healthcare provision, vaccination or displacement of people. The mechanism and treatment of toxin-mediated disease is well understood, however there are key gaps in our knowledge on the basic biology of particularly relating to host colonisation, the nature of asymptomatic carriage, population genomics and host adaptation.

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Keyword(s): actinobacteria , Corynebacterium diphtheriae , diphtheria , exotoxin and toxin
© 2018 The Authors
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/content/journal/micro/10.1099/mic.0.000627
2018-06-01
2024-04-20
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