1887

Abstract

Peptide metabolism forms an important part of the metabolic network of and to acquire these peptides the pathogen possesses a number of peptide transporters. Whilst various peptide transporters known in are well studied, very little is known about the carbon starvation () genes and , which are also predicted to be involved in peptide metabolism. We investigated the role of these genes in the metabolism and pathogenesis of , and demonstrated for the first time, to the best of our knowledge, that genes actually participate in transport of specific peptides in . Furthermore, we established that the carbon starvation gene affects the expression of flagella, leading to poor adhesion of the bacterium to host cells. In contrast to the previously reported role of in virulence of in , we showed that is required for successful colonization of in the mouse gut. Thus, genes not only contribute to the metabolism of , but also influence its virulence.

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2016-01-01
2021-10-27
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