1887

Abstract

is one of the most frequent aetiological factors of staphylococcal infections. This species seems to lack the important virulence attributes described in other staphylococci. However, studies have shown that the presence of various enzymes, cytolysins and surface substances affects the virulence of . Nevertheless, none of them has been identified as crucial and determinative. Despite this, is, after , the second most frequently isolated coagulase-negative staphylococcus from clinical cases, notably from blood infections, including sepsis. This raises the question of what is the reason for the increasing clinical significance of ? The most important factor might be the ability to acquire multiresistance against available antimicrobial agents, even glycopeptides. The unusual genome plasticity of strains manifested by a large number of insertion sequences and identified SNPs might contribute to its acquisition of antibiotic resistance. Interspecies transfer of SCC cassettes suggests that might also be the reservoir of resistance genes for other staphylococci, including . Taking into consideration the great adaptability and the ability to survive in the hospital environment, especially on medical devices, becomes a crucial factor in nosocomial infections caused by multiresistant staphylococci.

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2015-11-01
2024-12-07
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References

  1. Ahlstrand E., Svensson K., Persson L., Tidefelt U., Söderquist B. (2011). Glycopeptide resistance in coagulase-negative staphylococci isolated in blood cultures from patients with hematological malignancies during three decadesEur J Clin Microbiol Infect Dis 3013491354 [View Article][PubMed]. [Google Scholar]
  2. Andrews J., Ashby J., Jevons G., Marshall T., Lines N., Wise R. (2000). A comparison of antimicrobial resistance rates in Gram-positive pathogens isolated in the UK from October 1996 to January 1997 and October 1997 to January 1998J Antimicrob Chemother 45285293 [View Article][PubMed]. [Google Scholar]
  3. Archer G.L., Climo M.W. (1994). Antimicrobial susceptibility of coagulase-negative staphylococciAntimicrob Agents Chemother 3822312237 [View Article][PubMed]. [Google Scholar]
  4. Arciola C.R., Campoccia D., Montanaro L. (2002). Detection of biofilm-forming strains of Staphylococcus epidermidis and S. aureus Expert Rev Mol Diagn 2478484 [View Article][PubMed]. [Google Scholar]
  5. Aubert G., Passot S., Lucht F., Dorche G. (1990). Selection of vancomycin- and teicoplanin-resistant Staphylococcus haemolyticus during teicoplanin treatment of S. epidermidis infectionJ Antimicrob Chemother 25491493 [View Article][PubMed]. [Google Scholar]
  6. Bannerman T.L., Wadiak D.L., Kloos W.E. (1991). Susceptibility of Staphylococcus species and subspecies to teicoplaninAntimicrob Agents Chemother 3519191922 [View Article][PubMed]. [Google Scholar]
  7. Barros E.M., Ceotto H., Bastos M.C.F., Dos Santos K.R.N., Giambiagi-Demarval M. (2012). Staphylococcus haemolyticus as an important hospital pathogen and carrier of methicillin resistance genesJ Clin Microbiol 50166168 [View Article][PubMed]. [Google Scholar]
  8. Barros E.M., Lemos M., Souto-Padrón T., Giambiagi-deMarval M. (2015). Phenotypic and genotypic characterization of biofilm formation in Staphylococcus haemolyticus Curr Microbiol 70829834 [View Article][PubMed]. [Google Scholar]
  9. Becker K., Heilmann C., Peters G. (2014). Coagulase-negative staphylococciClin Microbiol Rev 27870926 [View Article][PubMed]. [Google Scholar]
  10. Berglund C., Söderquist B. (2008). The origin of a methicillin-resistant Staphylococcus aureus isolate at a neonatal ward in Sweden-possible horizontal transfer of a staphylococcal cassette chromosome mec between methicillin-resistant Staphylococcus haemolyticus and Staphylococcus aureus Clin Microbiol Infect 1410481056 [View Article][PubMed]. [Google Scholar]
  11. Biavasco F., Vignaroli C., Varaldo P.E. (2000). Glycopeptide resistance in coagulase-negative staphylococciEur J Clin Microbiol Infect Dis 19403417 [View Article][PubMed]. [Google Scholar]
  12. Billot-Klein D., Gutmann L., Bryant D., Bell D., Van Heijenoort J., Grewal J., Shlaes D.M. (1996). Peptidoglycan synthesis and structure in Staphylococcus haemolyticus expressing increasing levels of resistance to glycopeptide antibioticsJ Bacteriol 17846964703[PubMed]. [Google Scholar]
  13. Blans M., Troelstra A. (2001). Glycopeptide resistance in Staphylococcus haemolyticus during treatment with teicoplaninInfect Control Hosp Epidemiol 22263264 [View Article][PubMed]. [Google Scholar]
  14. Bochniarz M., Wawron W., Szczubiał M. (2013). Resistance to methicillin of coagulase-negative staphylococci (CNS) isolated from bovine mastitisPol J Vet Sci 16687692[PubMed]. [Google Scholar]
  15. Campanile F., Bongiorno D., Borbone S., Falcone M., Giannella M., Venditti M., Stefani S. (2008). In vitro activity of daptomycin against methicillin- and multi-resistant Staphylococcus haemolyticus invasive isolates carrying different mec complexesDiagn Microbiol Infect Dis 61227231 [View Article][PubMed]. [Google Scholar]
  16. Cavanagh J.P., Hjerde E., Holden M.T.G., Kahlke T., Klingenberg C., Flægstad T., Parkhill J., Bentley S.D., Sollid J.U.E. (2014). Whole-genome sequencing reveals clonal expansion of multiresistant Staphylococcus haemolyticus in European hospitalsJ Antimicrob Chemother 6929202927 [View Article][PubMed]. [Google Scholar]
  17. Cercenado E., García-Leoni M.E., Díaz M.D., Sánchez-Carrillo C., Catalán P., De Quirós J.C., Bouza E. (1996). Emergence of teicoplanin-resistant coagulase-negative staphylococciJ Clin Microbiol 3417651768[PubMed]. [Google Scholar]
  18. Chambers H.F. (1988). Methicillin-resistant staphylococciClin Microbiol Rev 1173186[PubMed]. [Google Scholar]
  19. Cidral T.A., Carvalho M.C., Figueiredo A.M.S., de Melo M.C.N. (2015). [Epub ahead of print]. Emergence of methicillin-resistant coagulase-negative staphylococci resistant to linezolid with rRNA gene C2190T and G2603T mutationsAPMIS. [View Article][PubMed] [Google Scholar]
  20. Corse J., Williams R.E. (1968). Antibiotic resistance of coagulase-negative staphylococci and micrococciJ Clin Pathol 21722728 [View Article][PubMed]. [Google Scholar]
  21. Cunningham R., Gurnell M., Bayston R., Cockayne A., Shelton A. (1997). Teicoplanin resistance in Staphylococcus haemolyticus, developing during treatmentJ Antimicrob Chemother 39438439 [View Article][PubMed]. [Google Scholar]
  22. Daniel B., Saleem M., Naseer G., Fida A. (2014). Significance of Staphylococcus haemolyticus in hospital acquired infectionsJ Pioneer Med Sci 4119126. [Google Scholar]
  23. Degener J.E., Heck M.E.C., van Leeuwen W.J., Heemskerk C., Crielaard A., Joosten P., Caesar P. (1994). Nosocomial infection by Staphylococcus haemolyticus and typing methods for epidemiological studyJ Clin Microbiol 3222602265[PubMed]. [Google Scholar]
  24. Eng R.H.K., Wang C., Person A., Kiehn T.E., Armstrong D. (1982). Species identification of coagulase-negative staphylococcal isolates from blood culturesJ Clin Microbiol 15439442[PubMed]. [Google Scholar]
  25. Enright M.C., Robinson D.A., Randle G., Feil E.J., Grundmann H., Spratt B.G. (2002). The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)Proc Natl Acad Sci U S A 9976877692 [View Article][PubMed]. [Google Scholar]
  26. Fajardo Olivares M., Hidalgo Orozco R., Rodríguez Garrido S., Rodríguez-Vidigal F.F., Vera Tomé A., Robles Marcos M. (2011). Activity of vancomycin, ciprofloxacin, daptomycin, and linezolid against coagulase-negative staphylococci bacteremiaRev Esp Quimioter 247478[PubMed]. [Google Scholar]
  27. Flahaut S., Vinogradov E., Kelley K.A., Brennan S., Hiramatsu K., Lee J.C. (2008). Structural and biological characterization of a capsular polysaccharide produced by Staphylococcus haemolyticus J Bacteriol 19016491657 [View Article][PubMed]. [Google Scholar]
  28. Fluit A.C., Carpaij N., Majoor E.A., Bonten M.J.M., Willems R.J.L. (2013). Shared reservoir of ccrB gene sequences between coagulase-negative staphylococci and methicillin-resistant Staphylococcus aureus J Antimicrob Chemother 6817071713 [View Article][PubMed]. [Google Scholar]
  29. Fredheim E.G.A., Klingenberg C., Rohde H., Frankenberger S., Gaustad P., Flaegstad T., Sollid J.E. (2009). Biofilm formation by Staphylococcus haemolyticus J Clin Microbiol 4711721180 [View Article][PubMed]. [Google Scholar]
  30. Froggatt J.W., Johnston J.L., Galetto D.W., Archer G.L. (1989). Antimicrobial resistance in nosocomial isolates of Staphylococcus haemolyticus Antimicrob Agents Chemother 33460466 [View Article][PubMed]. [Google Scholar]
  31. Gemmell C.G., Dawson J.E. (1982). Identification of coagulase-negative staphylococci with the API staph systemJ Clin Microbiol 16874877[PubMed]. [Google Scholar]
  32. Goldstein F.W., Coutrot A., Sieffer A., Acar J.F. (1990). Percentages and distributions of teicoplanin- and vancomycin-resistant strains among coagulase-negative staphylococciAntimicrob Agents Chemother 34899900 [View Article][PubMed]. [Google Scholar]
  33. Gupta V., Garg S., Jain R., Garg S., Chander J. (2012). Linezolid resistant Staphylococcus haemolyticus: first case report from IndiaAsian Pac J Trop Med 5837838 [View Article][PubMed]. [Google Scholar]
  34. Hanssen A.M., Ericson Sollid J.U. (2006). SCCmec in staphylococci: genes on the moveFEMS Immunol Med Microbiol 46820 [View Article][PubMed]. [Google Scholar]
  35. Hiramatsu K., Katayama Y., Yuzawa H., Ito T. (2002). Molecular genetics of methicillin-resistant Staphylococcus aureus Int J Med Microbiol 2926774 [View Article][PubMed]. [Google Scholar]
  36. Holden M.T.G., Hsu L.Y., Kurt K., Weinert L.A., Mather A.E., Harris S.R., Strommenger B., Layer F., Witte W., other authors. (2013). A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemicGenome Res 23653664 [View Article][PubMed]. [Google Scholar]
  37. Hope R., Livermore D.M., Brick G., Lillie M., Reynolds R., BSAC Working Parties on Resistance Surveillance. (2008). Non-susceptibility trends among staphylococci from bacteraemias in the UK and Ireland, 2001–06J Antimicrob Chemother 62(Suppl 2), ii65ii74[PubMed]. [Google Scholar]
  38. International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (2009). Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elementsAntimicrob Agents Chemother 5349614967 [View Article][PubMed]. [Google Scholar]
  39. Ito T., Katayama Y., Asada K., Mori N., Tsutsumimoto K., Tiensasitorn C., Hiramatsu K. (2001). Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus Antimicrob Agents Chemother 4513231336 [View Article][PubMed]. [Google Scholar]
  40. John J.F., Harvin A.M. (2007). History and evolution of antibiotic resistance in coagulase-negative staphylococci: susceptibility profiles of new anti-staphylococcal agentsTher Clin Risk Manag 311431152[PubMed]. [Google Scholar]
  41. John J.F. Jr, Gramling P.K., O'Dell N.M. (1978). Species identification of coagulase-negative staphylococci from urinary tract isolatesJ Clin Microbiol 8435437[PubMed]. [Google Scholar]
  42. Kim J.S., Kim H.S., Park J.Y., Koo H.S., Choi C.S., Song W., Cho H.C., Lee K.M. (2012). Contamination of X-ray cassettes with methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus haemolyticus in a radiology departmentAnn Lab Med 32206209 [View Article][PubMed]. [Google Scholar]
  43. Klingenberg C., Rønnestad A., Anderson A.S., Abrahamsen T.G., Zorman J., Villaruz A., Flaegstad T., Otto M., Sollid J.E. (2007). Persistent strains of coagulase-negative staphylococci in a neonatal intensive care unit: virulence factors and invasivenessClin Microbiol Infect 1311001111 [View Article][PubMed]. [Google Scholar]
  44. Kloos W.E., Schleifer K.H. (1975). Simplified scheme for routine identification of human Staphylococcus speciesJ Clin Microbiol 18288[PubMed]. [Google Scholar]
  45. Kollef M.H. (2009). New antimicrobial agents for methicillin-resistant Staphylococcus aureus Crit Care Resusc 11282286[PubMed]. [Google Scholar]
  46. Konstantinidis K.T., Ramette A., Tiedje J.M. (2006). The bacterial species definition in the genomic eraPhilos Trans R Soc Lond B Biol Sci 36119291940 [View Article][PubMed]. [Google Scholar]
  47. Kristóf K., Kocsis E., Szabó D., Kardos S., Cser V., Nagy K., Hermann P., Rozgonyi F. (2011). Significance of methicillin-teicoplanin resistant Staphylococcus haemolyticus in bloodstream infections in patients of the Semmelweis University hospitals in HungaryEur J Clin Microbiol Infect Dis 30691699 [View Article][PubMed]. [Google Scholar]
  48. Lamers R.P., Muthukrishnan G., Castoe T.A., Tafur S., Cole A.M., Parkinson C.L. (2012). Phylogenetic relationships among Staphylococcus species and refinement of cluster groups based on multilocus dataBMC Evol Biol 12171 [View Article][PubMed]. [Google Scholar]
  49. Lebeaux D., Barbier F., Angebault C., Benmahdi L., Ruppé E., Felix B., Gaillard K., Djossou F., Epelboin L., other authors. (2012). Evolution of nasal carriage of methicillin-resistant coagulase-negative staphylococci in a remote populationAntimicrob Agents Chemother 56315323 [View Article][PubMed]. [Google Scholar]
  50. Liakopoulos V., Petinaki E., Efthimiadi G., Klapsa D., Giannopoulou M., Dovas S., Eleftheriadis T., Mertens P.R., Stefanidis I. (2008). Clonal relatedness of methicillin-resistant coagulase-negative staphylococci in the haemodialysis unit of a single university centre in GreeceNephrol Dial Transplant 2325992603 [View Article][PubMed]. [Google Scholar]
  51. Liekweg W.G. Jr, Greenfield L.J. (1977). Vascular prosthetic infections: collected experience and results of treatmentSurgery 81335342[PubMed]. [Google Scholar]
  52. Livermore D.M. (2003). Linezolid in vitro: mechanism and antibacterial spectrumJ Antimicrob Chemother 51(Suppl 2), ii9ii16[PubMed]. [Google Scholar]
  53. Lloyd D.H. (2007). Reservoirs of antimicrobial resistance in pet animalsClin Infect Dis 45(Suppl 2), S148S152 [View Article][PubMed]. [Google Scholar]
  54. Long K.S., Vester B. (2012). Resistance to linezolid caused by modifications at its binding site on the ribosomeAntimicrob Agents Chemother 56603612 [View Article][PubMed]. [Google Scholar]
  55. Martin M.A., Pfaller M.A., Wenzel R.P. (1989). Coagulase-negative staphylococcal bacteremiaMortality and hospital stay. Ann Intern Med 110916 [View Article][PubMed]. [Google Scholar]
  56. Mazzariol A., Lo Cascio G., Kocsis E., Maccacaro L., Fontana R., Cornaglia G. (2012). Outbreak of linezolid-resistant Staphylococcus haemolyticus in an Italian intensive care unitEur J Clin Microbiol Infect Dis 31523527 [View Article][PubMed]. [Google Scholar]
  57. Mendes R.E., Flamm R.K., Hogan P.A., Ross J.E., Jones R.N. (2014a). Summary of linezolid activity and resistance mechanisms detected during the 2012 LEADER surveillance program for the United StatesAntimicrob Agents Chemother 5812431247 [View Article][PubMed]. [Google Scholar]
  58. Mendes R.E., Hogan P.A., Streit J.M., Jones R.N., Flamm R.K. (2014b). Zyvox® Annual Appraisal of Potency and Spectrum (ZAAPS) program: report of linezolid activity over 9 years (2004-12)J Antimicrob Chemother 6915821588 [View Article][PubMed]. [Google Scholar]
  59. Mendes R.E., Deshpande L.M., Jones R.N. (2014c). Linezolid update: stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanismsDrug Resist Updat 17112 [View Article][PubMed]. [Google Scholar]
  60. Miragaia M., Thomas J.C., Couto I., Enright M.C., de Lencastre H. (2007). Inferring a population structure for Staphylococcus epidermidis from multilocus sequence typing dataJ Bacteriol 18925402552 [View Article][PubMed]. [Google Scholar]
  61. Młynarczyk A., Młynarczyk G. (2008). [Molecular mechanisms of resistance to antimicrobial agents in Staphylococcus aureus]Postępy Mikrobiol 47423429(in Polish). [Google Scholar]
  62. Nakipoglu Y., Derbentli S., Cagatay A.A., Katranci H. (2005). Investigation of Staphylococcus strains with heterogeneous resistance to glycopeptides in a Turkish university hospitalBMC Infect Dis 531 [View Article][PubMed]. [Google Scholar]
  63. Natoli S., Fontana C., Favaro M., Bergamini A., Testore G.P., Minelli S., Bossa M.C., Casapulla M., Broglio G., other authors. (2009). Characterization of coagulase-negative staphylococcal isolates from blood with reduced susceptibility to glycopeptides and therapeutic optionsBMC Infect Dis 983 [View Article][PubMed]. [Google Scholar]
  64. Otto M. (2014). Staphylococcus aureus toxinsCurr Opin Microbiol 173237[PubMed]>.[CrossRef] [Google Scholar]
  65. Pereira P.M.A., Binatti V.B., Sued B.P.R., Ramos J.N., Peixoto R.S., Simões C., de Castro E.A., Duarte J.L.M.B., Vieira V.V., other authors. (2014). Staphylococcus haemolyticus disseminated among neonates with bacteremia in a neonatal intensive care unit in Rio de JaneiroBrazil. Diagn Microbiol Infect Dis 788592 [View Article][PubMed]. [Google Scholar]
  66. Perl T.M., Krüger W.A., Houston A., Boyken L.D., Pfaller M.A., Herwaldt L.A. (1999). Investigation of suspected nosocomial clusters of Staphylococcus haemolyticus infectionsInfect Control Hosp Epidemiol 20128131 [View Article][PubMed]. [Google Scholar]
  67. Perry C.M., Jarvis B. (2001). Linezolid: a review of its use in the management of serious gram-positive infectionsDrugs 61525551 [View Article][PubMed]. [Google Scholar]
  68. Quiles-Melero I., Gómez-Gil R., Romero-Gómez M.P., Sánchez-Díaz A.M., de Pablos M., García-Rodriguez J., Gutiérrez A., Mingorance J. (2013). Mechanisms of linezolid resistance among staphylococci in a tertiary hospitalJ Clin Microbiol 519981001 [View Article][PubMed]. [Google Scholar]
  69. Qureshi N.K., Yin S., Boyle-Vavra S. (2014). The role of the Staphylococcal VraTSR regulatory system on vancomycin resistance and vanA operon expression in vancomycin-resistant Staphylococcus aureus PLoS One 9e85873 [View Article][PubMed]. [Google Scholar]
  70. Rahman A., Hosaain M.A., Mahmud C., Paul S.K., Sultana S., Haque N., Kabir M.R., Kubayashi N. (2012). Species distribution of coagulase negative staphylococci isolated from different clinical specimensMymensingh Med J 21195199[PubMed]. [Google Scholar]
  71. Rajan V., Kumar V.G., Gopal S. (2014). cfr-positive clinical staphylococcal isolate from India with multiple mechanisms of linezolid-resistanceIndian J Med Res 139463467[PubMed]. [Google Scholar]
  72. Rice L.B. (2012). Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolonesMayo Clin Proc 87198208 [View Article][PubMed]. [Google Scholar]
  73. Rodríguez-Aranda A., Daskalaki M., Villar J., Sanz F., Otero J.R., Chaves F. (2009). Nosocomial spread of linezolid-resistant Staphylococcus haemolyticus infections in an intensive care unitDiagn Microbiol Infect Dis 63398402 [View Article][PubMed]. [Google Scholar]
  74. Rosenstein R., Götz F. (2013). What distinguishes highly pathogenic staphylococci from medium- and non-pathogenic?Curr Top Microbiol Immunol 3583389[PubMed]. [Google Scholar]
  75. Rupp M.E., Archer G.L. (1994). Coagulase-negative staphylococci: pathogens associated with medical progressClin Infect Dis 19231245 [View Article][PubMed]. [Google Scholar]
  76. Ruzauskas M., Siugzdiniene R., Klimiene I., Virgailis M., Mockeliunas R., Vaskeviciute L., Zienius D. (2014). Prevalence of methicillin-resistant Staphylococcus haemolyticus in companion animals: a cross-sectional studyAnn Clin Microbiol Antimicrob 1356 [View Article][PubMed]. [Google Scholar]
  77. Schaberg D.R., Culver D.H., Gaynes R.P. (1991). Major trends in the microbial etiology of nosocomial infectionAm J Med 91(3B), 72S75S [View Article][PubMed]. [Google Scholar]
  78. Schwalbe R.S., Stapleton J.T., Gilligan P.H. (1987). Emergence of vancomycin resistance in coagulase-negative staphylococciN Engl J Med 316927931 [View Article][PubMed]. [Google Scholar]
  79. Shittu A., Lin J., Morrison D., Kolawole D. (2004). Isolation and molecular characterization of multiresistant Staphylococcus sciuri and Staphylococcus haemolyticus associated with skin and soft-tissue infectionsJ Med Microbiol 535155 [View Article][PubMed]. [Google Scholar]
  80. Shore A.C., Coleman D.C. (2013). Staphylococcal cassette chromosome mec: recent advances and new insightsInt J Med Microbiol 303350359 [View Article][PubMed]. [Google Scholar]
  81. Siebert W.T., Moreland N., Williams T.W. Jr (1979). Synergy of vancomycin plus cefazolin or cephalothin against methicillin-resistance Staphylococcus epidermidis J Infect Dis 139452457 [View Article][PubMed]. [Google Scholar]
  82. Sieradzki K., Villari P., Tomasz A. (1998). Decreased susceptibilities to teicoplanin and vancomycin among coagulase-negative methicillin-resistant clinical isolates of staphylococciAntimicrob Agents Chemother 42100107[PubMed]. [Google Scholar]
  83. Silva P.V., Cruz R.S., Keim L.S., Paula G.R., Carvalho B.T., Coelho L.R., Carvalho M.C., Rosa J.M., Figueiredo A.M.S., Teixeira L.A. (2013). The antimicrobial susceptibility, biofilm formation and genotypic profiles of Staphylococcus haemolyticus from bloodstream infectionsMem Inst Oswaldo Cruz 108812813 [View Article][PubMed]. [Google Scholar]
  84. Simango C. (2005). Characterisation of Staphylococcus haemolyticus isolated from urinary tract infectionsCent Afr J Med 51112114[PubMed]. [Google Scholar]
  85. Sloos J.H., van de Klundert J.A., Dijkshoorn L., van Boven C.P. (1998). Changing susceptibilities of coagulase-negative staphylococci to teicoplanin in a teaching hospitalJ Antimicrob Chemother 42787791 [View Article][PubMed]. [Google Scholar]
  86. Squeri R., Grillo O.C., La Fauci V. (2012). Surveillance and evidence of contamination in hospital environment from meticillin and vancomycin-resistant microbial agentsJ Prev Med Hyg 53143145[PubMed]. [Google Scholar]
  87. Srinivasan A., Dick J.D., Perl T.M. (2002). Vancomycin resistance in staphylococciClin Microbiol Rev 15430438 [View Article][PubMed]. [Google Scholar]
  88. Stewart G.T. (1961). Changes in sensitivity of stapphylococci to methicillinBMJ 1863866 [View Article][PubMed]. [Google Scholar]
  89. Sutherland R., Rolinson G.N. (1964). Characteristics of methicillin-resistant staphylococciJ Bacteriol 87887899[PubMed]. [Google Scholar]
  90. Szczuka E., Kaznowski A. (2014). [The diversity of SCCmec cassettes with methicillin-resistant coagulase-negative staphylococci]Post Mikrobiol 53223228(in Polish). [Google Scholar]
  91. Tabe Y., Nakamura A., Igari J. (2001). Glycopeptide susceptibility profiles of nosocomial multiresistant Staphylococcus haemolyticus isolatesJ Infect Chemother 7142147 [View Article][PubMed]. [Google Scholar]
  92. Tabe Y., Nakamura A., Oguri T., Igari J. (1998). Molecular Characterization of Epidemic Multiresistant Staphylococcus haemolyticus IsolatesDiagn Microbiol Infect Dis 32177183 [View Article][PubMed]. [Google Scholar]
  93. Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., other authors. (2005). Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal speciesJ Bacteriol 18772927308 [View Article][PubMed]. [Google Scholar]
  94. Tarazona R.E.R., Padilla T.P., Gómez J.C.S., Sánchez J.E.G., Hernandez M.S. (2007). First report in Spain of linezolid non-susceptibility in a clinical isolate of Staphylococcus haemolyticus Int J Antimicrob Agents 30277278 [View Article][PubMed]. [Google Scholar]
  95. Ternes Y.M., Lamaro-Cardoso J., André M.C., Pessoa V.P. Jr, Vieira M.A., Minamisava R., Andrade A.L., Kipnis A. (2013). Molecular epidemiology of coagulase-negative Staphylococcus carriage in neonates admitted to an intensive care unit in BrazilBMC Infect Dis 13572 [View Article][PubMed]. [Google Scholar]
  96. Tormo M.Á., Knecht E., Götz F., Lasa I., Penadés J.R. (2005). Bap-dependent biofilm formation by pathogenic species of Staphylococcus: evidence of horizontal gene transfer?Microbiology 15124652475 [View Article][PubMed]. [Google Scholar]
  97. Tsiodras S., Gold H.S., Sakoulas G., Eliopoulos G.M., Wennersten C., Venkataraman L., Moellering R.C. Jr, Ferraro M.J. (2001). Linezolid resistance in a clinical isolate of Staphylococcus aureus Lancet 358207208 [View Article][PubMed]. [Google Scholar]
  98. Tuazon C.U., Miller H. (1983). Clinical and microbiologic aspects of serious infections caused by Staphylococcus epidermidis Scand J Infect Dis 15347360 [View Article][PubMed]. [Google Scholar]
  99. Vanderhaeghen W., Piepers S., Leroy F., Van Coillie E., Haesebrouck F., De Vliegher S. (2014). Invited review: effect, persistence, and virulence of coagulase-negative Staphylococcus species associated with ruminant udder healthJ Dairy Sci 9752755293 [View Article][PubMed]. [Google Scholar]
  100. Veach L.A., Pfaller M.A., Barrett M., Koontz F.P., Wenzel R.P. (1990). Vancomycin resistance in Staphylococcus haemolyticus causing colonization and bloodstream infectionJ Clin Microbiol 2820642068[PubMed]. [Google Scholar]
  101. Vos P., Garrity G., Jones D., Krieg N.R., Ludwig W., Rainey F.A., Schleifer K.-H., Whitman W. (2009). Bergey's Manual of Systematic BacteriologyVolume 3: The Firmicutes New YorkSpringer. [Google Scholar]
  102. Widmer A.F. (2008). Ceftobiprole: a new option for treatment of skin and soft-tissue infections due to methicillin-resistant Staphylococcus aureus Clin Infect Dis 46656658 [View Article][PubMed]. [Google Scholar]
  103. Zhang L., Thomas J.C., Miragaia M., Bouchami O., Chaves F., d'Azevedo P.A., Aanensen D.M., de Lencastre H., Gray B.M., Robinson D.A. (2013). Multilocus sequence typing and further genetic characterization of the enigmatic pathogen, Staphylococcus hominis PLoS One 8e66496 [View Article][PubMed]. [Google Scholar]
  104. Zong Z., Peng C., X. (2011). Diversity of SCCmec elements in methicillin-resistant coagulase-negative staphylococci clinical isolatesPLoS One 6e20191 .[CrossRef] [Google Scholar]
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