1887

Abstract

is the leading cause of nosocomial infections, particularly in immunocompromised, cancer, burn and cystic fibrosis patients. Development of novel antimicrobials against is therefore of the highest importance. Although the first reports on essential genes date back to the early 2000s, a number of more sensitive genomic approaches have been used recently to better define essential genes in this organism. These analyses highlight the evolution of the definition of an ‘essential’ gene from the traditional to the context-dependent. Essential genes, particularly those indispensable under the clinically relevant conditions, are considered to be promising targets of novel antibiotics against . This review provides an update on the investigation of essential genes. Special focus is on recently identified essential genes and their exploitation for the development of antimicrobials.

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2015-11-01
2022-01-16
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