1887

Abstract

is an oral bacterium that has been shown to be associated with inflammatory bowel disease (IBD). In this study we examined clusters of oral strains isolated from patients with IBD and healthy controls by analysing six housekeeping genes. In addition, we investigated the population structure of strains. Whether oral and enteric strains form distinct clusters based on the sequences of these housekeeping genes was also investigated. The oral strains were found to contain two genomospecies, which belong to the two genomospecies previously found in enteric strains. clusters formed based on the sequences of a single gene were the same as that formed by using previously reported MLST schemes. The analysis of combined oral and enteric strains found that enteric strains did not form distinct clusters. Genetic structure analysis identified five subpopulations of and showed that genetic recombination between strains was common. However, genetic recombination was significantly less in oral strains isolated from patients with IBD than from healthy individuals. Previously reported oral and enteric intestinal epithelial invasive strains were in cluster II and subpopulation III. Furthermore, this study shows that there are no distinct enteric strain clusters or subpopulations.

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2015-08-01
2020-03-29
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