1887

Abstract

Integrons are genetic elements that contain a site-specific recombination system able to capture, express and exchange gene cassettes. Mobile integrons are widespread and often confer resistance to multiple antibiotics, due to the expression of the arrays of gene cassettes they carry. Although >300 cassette arrays have been described, < 10 array compositions prevail in the reports related to class 1 integrons. These common arrays are found in a broad variety of hosts and environments, highlighting the high level of horizontal dissemination of these elements amongst bacterial populations and species. Clonal expansion also contributes to the current prevalence and inter-regional spread of integron-carrying bacterial species. Here, we review the dissemination pattern of common cassette arrays with a focus on the bacterial species, the geographical dispersal pattern and the environments in which they reside. Conserved arrays of gene cassettes are found in at least 74 countries and 72 species present in different environments. The factors governing the further spread and population dynamics of these cassette arrays remain to be determined.

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2015-07-01
2019-12-15
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References

  1. Adabi M. , Bakhshi B. , Goudarzi H. , Zahraei S.M. , Pourshafie M.R. . ( 2009;). Distribution of class I integron and sulfamethoxazole trimethoprim constin in Vibrio cholerae isolated from patients in Iran. Microb Drug Resist 15: 179–184 [CrossRef] [PubMed].
    [Google Scholar]
  2. Ahmed A.M. , Shimamoto T. . ( 2011;). Molecular characterization of antimicrobial resistance in Gram-negative bacteria isolated from bovine mastitis in Egypt. Microbiol Immunol 55: 318–327 [CrossRef] [PubMed].
    [Google Scholar]
  3. Ahmed A.M. , Nakano H. , Shimamoto T. . ( 2005;). Molecular characterization of integrons in non-typhoid Salmonella serovars isolated in Japan: description of an unusual class 2 integron. J Antimicrob Chemother 55: 371–374 [CrossRef] [PubMed].
    [Google Scholar]
  4. Ahmed A.M. , Motoi Y. , Sato M. , Maruyama A. , Watanabe H. , Fukumoto Y. , Shimamoto T. . ( 2007;). Zoo animals as reservoirs of Gram-negative bacteria harboring integrons and antimicrobial resistance genes. Appl Environ Microbiol 73: 6686–6690 [CrossRef] [PubMed].
    [Google Scholar]
  5. Ahmed A.M. , Shimabukuro H. , Shimamoto T. . ( 2009a;). Isolation and molecular characterization of multidrug-resistant strains of Escherichia coli Salmonella from retail chicken meat in Japan. J Food Sci 74: M405–M410 [CrossRef] [PubMed].
    [Google Scholar]
  6. Ahmed A.M. , Younis E.E. , Osman S.A. , Ishida Y. , El-Khodery S.A. , Shimamoto T. . ( 2009b;). Genetic analysis of antimicrobial resistance in Escherichia coli isolated from diarrheic neonatal calves. Vet Microbiol 136: 397–402 [CrossRef] [PubMed].
    [Google Scholar]
  7. Aibinu I. , Pfeifer Y. , Peters F. , Ogunsola F. , Adenipekun E. , Odugbemi T. , Koenig W. . ( 2012;). Emergence of bla CTX-M-15 qnrB1 aac(6′)-Ib-cr resistance genes in Pantoea agglomerans Enterobacter cloacae from Nigeria (sub-Saharan Africa). J Med Microbiol 61: 165–167 [CrossRef] [PubMed].
    [Google Scholar]
  8. Ajiboye R.M. , Solberg O.D. , Lee B.M. , Raphael E. , Debroy C. , Riley L.W. . ( 2009;). Global spread of mobile antimicrobial drug resistance determinants in human and animal Escherichia coli Salmonella strains causing community-acquired infections. Clin Infect Dis 49: 365–371 [CrossRef] [PubMed].
    [Google Scholar]
  9. Al-Sanouri T.M. , Paglietti B. , Haddadin A. , Murgia M. , Bacciu D. , Youssef M. , Rubino S. . ( 2008;). Emergence of plasmid-mediated multidrug resistance in epidemic and non-epidemic strains of Salmonella enterica serotype Typhi from Jordan. J Infect Dev Ctries 2: 295–301 [PubMed].
    [Google Scholar]
  10. Allen K.J. , Poppe C. . ( 2002;). Occurrence and characterization of resistance to extended-spectrum cephalosporins mediated by β-lactamase CMY-2 in Salmonella isolated from food-producing animals in Canada. Can J Vet Res 66: 137–144 [PubMed].
    [Google Scholar]
  11. Aminov R.I. . ( 2011;). Horizontal gene exchange in environmental microbiota. Front Microbiol 2: 158 [CrossRef] [PubMed].
    [Google Scholar]
  12. Antunes P. , Machado J. , Peixe L. . ( 2006;). Characterization of antimicrobial resistance and class 1 and 2 integrons in Salmonella enterica isolates from different sources in Portugal. J Antimicrob Chemother 58: 297–304 [CrossRef] [PubMed].
    [Google Scholar]
  13. Bado I. , Cordeiro N.F. , Robino L. , García-Fulgueiras V. , Seija V. , Bazet C. , Gutkind G. , Ayala J.A. , Vignoli R. . ( 2010;). Detection of class 1 and 2 integrons, extended-spectrum β-lactamases and qnr alleles in enterobacterial isolates from the digestive tract of Intensive Care Unit inpatients. Int J Antimicrob Agents 36: 453–458 [CrossRef] [PubMed].
    [Google Scholar]
  14. Baharoglu Z. , Mazel D. . ( 2011;). Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance. Antimicrob Agents Chemother 55: 2438–2441 [CrossRef] [PubMed].
    [Google Scholar]
  15. Baharoglu Z. , Bikard D. , Mazel D. . ( 2010;). Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation. PLoS Genet 6: e1001165 [CrossRef] [PubMed].
    [Google Scholar]
  16. Baharoglu Z. , Krin E. , Mazel D. . ( 2012;). Connecting environment and genome plasticity in the characterization of transformation-induced SOS regulation and carbon catabolite control of the Vibrio cholerae integron integrase. J Bacteriol 194: 1659–1667 [CrossRef] [PubMed].
    [Google Scholar]
  17. Bailey J.K. , Pinyon J.L. , Anantham S. , Hall R.M. . ( 2010;). Commensal Escherichia coli of healthy humans: a reservoir for antibiotic-resistance determinants. J Med Microbiol 59: 1331–1339 [CrossRef] [PubMed].
    [Google Scholar]
  18. Barlow R.S. , Fegan N. , Gobius K.S. . ( 2008;). A comparison of antibiotic resistance integrons in cattle from separate beef meat production systems at slaughter. J Appl Microbiol 104: 651–658 [CrossRef] [PubMed].
    [Google Scholar]
  19. Ben Sallem R. , Ben Slama K. , Sáenz Y. , Rojo-Bezares B. , Estepa V. , Jouini A. , Gharsa H. , Klibi N. , Boudabous A. , Torres C. . ( 2012;). Prevalence and characterization of extended-spectrum β-lactamase (ESBL)- and CMY-2-producing Escherichia coli isolates from healthy food-producing animals in Tunisia. Foodborne Pathog Dis 9: 1137–1142 [CrossRef] [PubMed].
    [Google Scholar]
  20. Ben Slama K. , Ben Sallem R. , Jouini A. , Rachid S. , Moussa L. , Sáenz Y. , Estepa V. , Somalo S. , Boudabous A. , Torres C. . ( 2011;). Diversity of genetic lineages among CTX-M-15 and CTX-M-14 producing Escherichia coli strains in a Tunisian hospital. Curr Microbiol 62: 1794–1801 [CrossRef] [PubMed].
    [Google Scholar]
  21. Bennett P.M. . ( 2008;). Plasmid encoded antibiotic resistance: acquisition and transfer of antibiotic resistance genes in bacteria. Br J Pharmacol 153: (Suppl 1), S347–S357 doi:10.1038/sj.bjp.0707607 [PubMed].
    [Google Scholar]
  22. Binh C.T. , Heuer H. , Kaupenjohann M. , Smalla K. . ( 2009;). Diverse aadA gene cassettes on class 1 integrons introduced into soil via spread manure. Res Microbiol 160: 427–433 [CrossRef] [PubMed].
    [Google Scholar]
  23. Blahna M.T. , Zalewski C.A. , Reuer J. , Kahlmeter G. , Foxman B. , Marrs C.F. . ( 2006;). The role of horizontal gene transfer in the spread of trimethoprim–sulfamethoxazole resistance among uropathogenic Escherichia coli in Europe and Canada. J Antimicrob Chemother 57: 666–672 [CrossRef] [PubMed].
    [Google Scholar]
  24. Boucher Y. , Labbate M. , Koenig J.E. , Stokes H.W. . ( 2007;). Integrons: mobilizable platforms that promote genetic diversity in bacteria. Trends Microbiol 15: 301–309 doi:10.1016/j.tim.2007.05.004 [PubMed].[CrossRef]
    [Google Scholar]
  25. Boyd D. , Peters G.A. , Cloeckaert A. , Boumedine K.S. , Chaslus-Dancla E. , Imberechts H. , Mulvey M.R. . ( 2001;). Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona. J Bacteriol 183: 5725–5732 [CrossRef] [PubMed].
    [Google Scholar]
  26. Boyd D. , Cloeckaert A. , Chaslus-Dancla E. , Mulvey M.R. . ( 2002;). Characterization of variant Salmonella genomic island 1 multidrug resistance regions from serovars Typhimurium DT104 and Agona. Antimicrob Agents Chemother 46: 1714–1722 [CrossRef] [PubMed].
    [Google Scholar]
  27. Boyd D.A. , Shi X. , Hu Q.H. , Ng L.K. , Doublet B. , Cloeckaert A. , Mulvey M.R. . ( 2008;). Salmonella genomic island 1 (SGI1), variant SGI1-I, and new variant SGI1-O in Proteus mirabilis clinical and food isolates from China. Antimicrob Agents Chemother 52: 340–344 [CrossRef] [PubMed].
    [Google Scholar]
  28. Caleja C. , de Toro M. , Gonçalves A. , Themudo P. , Vieira-Pinto M. , Monteiro D. , Rodrigues J. , Sáenz Y. , Carvalho C. , other authors . ( 2011;). Antimicrobial resistance and class I integrons in Salmonella enterica isolates from wild boars and Bísaro pigs. Int Microbiol 14: 19–24 [PubMed].
    [Google Scholar]
  29. Cambray G. , Guerout A.M. , Mazel D. . ( 2010;). Integrons. Annu Rev Genet 44: 141–166 [CrossRef] [PubMed].
    [Google Scholar]
  30. Cameron F.H. , Groot Obbink D.J. , Ackerman V.P. , Hall R.M. . ( 1986;). Nucleotide sequence of the AAD(2″) aminoglycoside adenylyltransferase determinant aadB. Evolutionary relationship of this region with those surrounding aadA in R538-1 and dhfrII in R388. Nucleic Acids Res 14: 8625–8635 [CrossRef] [PubMed].
    [Google Scholar]
  31. Carvalho M.J. , Martínez-Murcia A. , Esteves A.C. , Correia A. , Saavedra M.J. . ( 2012;). Phylogenetic diversity, antibiotic resistance and virulence traits of Aeromonas spp. from untreated waters for human consumption. Int J Food Microbiol 159: 230–239 [CrossRef] [PubMed].
    [Google Scholar]
  32. Casin I. , Breuil J. , Brisabois A. , Moury F. , Grimont F. , Collatz E. . ( 1999;). Multidrug-resistant human and animal Salmonella typhimurium isolates in France belong predominantly to a DT104 clone with the chromosome- and integron-encoded β-lactamase PSE-1. J Infect Dis 179: 1173–1182 [CrossRef] [PubMed].
    [Google Scholar]
  33. Ceccarelli D. , Bani S. , Cappuccinelli P. , Colombo M.M. . ( 2006a;). Prevalence of aadA1 dfrA15 class 1 integron cassettes and SXT circulation in Vibrio cholerae O1 isolates from Africa. J Antimicrob Chemother 58: 1095–1097 [CrossRef] [PubMed].
    [Google Scholar]
  34. Ceccarelli D. , Salvia A.M. , Sami J. , Cappuccinelli P. , Colombo M.M. . ( 2006b;). New cluster of plasmid-located class 1 integrons in Vibrio cholerae O1 and a dfrA15 cassette-containing integron in Vibrio parahaemolyticus isolated in Angola. Antimicrob Agents Chemother 50: 2493–2499 doi:10.1128/AAC.01310-05 [PubMed].[CrossRef]
    [Google Scholar]
  35. Chakraborty R. , Kumar A. , Bhowal S.S. , Mandal A.K. , Tiwary B.K. , Mukherjee S. . ( 2013;). Diverse gene cassettes in class 1 integrons of facultative oligotrophic bacteria of River Mahananda, West Bengal, India. PLoS One 8: e71753 [CrossRef] [PubMed].
    [Google Scholar]
  36. Chang C.Y. , Chang L.L. , Chang Y.H. , Lee T.M. , Chang S.F. . ( 2000;). Characterisation of drug resistance gene cassettes associated with class 1 integrons in clinical isolates of Escherichia coli from Taiwan, ROC. J Med Microbiol 49: 1097–1102 [PubMed].
    [Google Scholar]
  37. Chen H. , Shu W. , Chang X. , Chen J.A. , Guo Y. , Tan Y. . ( 2010;). The profile of antibiotics resistance and integrons of extended-spectrum β-lactamase producing thermotolerant coliforms isolated from the Yangtze River basin in Chongqing. Environ Pollut 158: 2459–2464 [CrossRef] [PubMed].
    [Google Scholar]
  38. Clark N.C. , Olsvik O. , Swenson J.M. , Spiegel C.A. , Tenover F.C. . ( 1999;). Detection of a streptomycin/spectinomycin adenylyltransferase gene (aadA) in Enterococcus faecalis . Antimicrob Agents Chemother 43: 157–160 [PubMed].[CrossRef]
    [Google Scholar]
  39. Collis C.M. , Hall R.M. . ( 1995;). Expression of antibiotic resistance genes in the integrated cassettes of integrons. Antimicrob Agents Chemother 39: 155–162 [CrossRef] [PubMed].
    [Google Scholar]
  40. Corkill J.E. , Anson J.J. , Hart C.A. . ( 2005;). High prevalence of the plasmid-mediated quinolone resistance determinant qnrA in multidrug-resistant Enterobacteriaceae from blood cultures in Liverpool. J Antimicrob Chemother 56: 1115–1117 [CrossRef] [PubMed].
    [Google Scholar]
  41. D'Costa V.M. , King C.E. , Kalan L. , Morar M. , Sung W.W. , Schwarz C. , Froese D. , Zazula G. , Calmels F. , other authors . ( 2011;). Antibiotic resistance is ancient. Nature 477: 457–461 [CrossRef] [PubMed].
    [Google Scholar]
  42. Dahmen S. , Mansour W. , Boujaafar N. , Arlet G. , Bouallègue O. . ( 2010;). Distribution of cotrimoxazole resistance genes associated with class 1 integrons in clinical isolates of Enterobacteriaceae in a university hospital in Tunisia. Microb Drug Resist 16: 43–47 [CrossRef] [PubMed].
    [Google Scholar]
  43. Dalsgaard A. , Forslund A. , Serichantalergs O. , Sandvang D. . ( 2000;). Distribution and content of class 1 integrons in different Vibrio cholerae O-serotype strains isolated in Thailand. Antimicrob Agents Chemother 44: 1315–1321 [CrossRef] [PubMed].
    [Google Scholar]
  44. Dalsgaard A. , Forslund A. , Sandvang D. , Arntzen L. , Keddy K. . ( 2001;). Vibrio cholerae O1 outbreak isolates in Mozambique and South Africa in 1998 are multiple-drug resistant, contain the SXT element and the aadA2 gene located on class 1 integrons. J Antimicrob Chemother 48: 827–838 [CrossRef] [PubMed].
    [Google Scholar]
  45. Dawes F.E. , Kuzevski A. , Bettelheim K.A. , Hornitzky M.A. , Djordjevic S.P. , Walker M.J. . ( 2010;). Distribution of class 1 integrons with IS26-mediated deletions in their 3′-conserved segments in Escherichia coli of human and animal origin. PLoS One 5: e12754 [CrossRef] [PubMed].
    [Google Scholar]
  46. Di Conza J. , Ayala J.A. , Porto A. , Mollerach M. , Gutkind G. . ( 2005;). Molecular characterization of InJR06, a class 1 integron located in a conjugative plasmid of Salmonella enterica ser. Typhimurium. Int Microbiol 8: 287–290 [PubMed].
    [Google Scholar]
  47. Dolejská M. , Senk D. , Cízek A. , Rybaríková J. , Sychra O. , Literák I. . ( 2008;). Antimicrobial resistant Escherichia coli isolates in cattle and house sparrows on two Czech dairy farms. Res Vet Sci 85: 491–494 [CrossRef] [PubMed].
    [Google Scholar]
  48. Dolejská M. , Bierosová B. , Kohoutová L. , Literák I. , Cízek A. . ( 2009;). Antibiotic-resistant Salmonella Escherichia coli isolates with integrons and extended-spectrum β-lactamases in surface water and sympatric black-headed gulls. J Appl Microbiol 106: 1941–1950 [CrossRef] [PubMed].
    [Google Scholar]
  49. Domingues S. , da Silva G.J. , Nielsen K.M. . ( 2012a;). Integrons: vehicles and pathways for horizontal dissemination in bacteria. Mob Genet Elements 2: 211–223 [CrossRef] [PubMed].
    [Google Scholar]
  50. Domingues S. , Nielsen K.M. , da Silva G.J. . ( 2012b;). Various pathways leading to the acquisition of antibiotic resistance by natural transformation. Mob Genet Elements 2: 257–260 [CrossRef] [PubMed].
    [Google Scholar]
  51. Domingues S. , Harms K. , Fricke W.F. , Johnsen P.J. , da Silva G.J. , Nielsen K.M. . ( 2012c;). Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species. PLoS Pathog 8: e1002837 [CrossRef] [PubMed].
    [Google Scholar]
  52. Dotto G. , Giacomelli M. , Grilli G. , Ferrazzi V. , Carattoli A. , Fortini D. , Piccirillo A. . ( 2014;). High prevalence of oqxAB in Escherichia coli isolates from domestic and wild lagomorphs in Italy. Microb Drug Resist 20: 118–123 [CrossRef] [PubMed].
    [Google Scholar]
  53. Doublet B. , Butaye P. , Imberechts H. , Boyd D. , Mulvey M.R. , Chaslus-Dancla E. , Cloeckaert A. . ( 2004;). Salmonella genomic island 1 multidrug resistance gene clusters in Salmonella enterica serovar Agona isolated in Belgium in 1992 to 2002. Antimicrob Agents Chemother 48: 2510–2517 [CrossRef] [PubMed].
    [Google Scholar]
  54. Du X. , Shen Z. , Wu B. , Xia S. , Shen J. . ( 2005;). Characterization of class 1 integrons-mediated antibiotic resistance among calf pathogenic Escherichia coli . FEMS Microbiol Lett 245: 295–298 [CrossRef] [PubMed].
    [Google Scholar]
  55. Egorova S. , Kaftyreva L. , Grimont P.A. , Weill F.X. . ( 2007;). Prevalence and characterization of extended-spectrum cephalosporin-resistant nontyphoidal Salmonella isolates in adults in Saint Petersburg, Russia (2002–2005). Microb Drug Resist 13: 102–107 [CrossRef] [PubMed].
    [Google Scholar]
  56. El-Najjar N.G. , Farah M.J. , Hashwa F.A. , Tokajian S.T. . ( 2010;). Antibiotic resistance patterns and sequencing of class I integron from uropathogenic Escherichia coli in Lebanon. Lett Appl Microbiol 51: 456–461 [CrossRef] [PubMed].
    [Google Scholar]
  57. Falbo V. , Carattoli A. , Tosini F. , Pezzella C. , Dionisi A.M. , Luzzi I. . ( 1999;). Antibiotic resistance conferred by a conjugative plasmid and a class I integron in Vibrio cholerae O1 El Tor strains isolated in Albania and Italy. Antimicrob Agents Chemother 43: 693–696 [PubMed].
    [Google Scholar]
  58. Falcone M. , Perilli M. , Mezzatesta M.L. , Mancini C. , Amicosante G. , Stefani S. , Venditti M. . ( 2010;). Prolonged bacteraemia caused by VIM-1 metallo-β-lactamase-producing Proteus mirabilis: first report from Italy. Clin Microbiol Infect 16: 179–181 [CrossRef] [PubMed].
    [Google Scholar]
  59. Feng J.L. , Yan H. , Chowdhury N. , Neogi S.B. , Yamasaki S. , Shi L. , Hu J. , Chen Q. . ( 2011;). Identification and characterization of integron-associated antibiotic resistant Laribacter hongkongensis isolated from aquatic products in China. Int J Food Microbiol 144: 337–341 [CrossRef] [PubMed].
    [Google Scholar]
  60. Ferreira da Silva M. , Vaz-Moreira I. , Gonzalez-Pajuelo M. , Nunes O.C. , Manaia C.M. . ( 2007;). Antimicrobial resistance patterns in Enterobacteriaceae isolated from an urban wastewater treatment plant. FEMS Microbiol Ecol 60: 166–176 [CrossRef] [PubMed].
    [Google Scholar]
  61. Fluit A.C. , Schmitz F.J. . ( 1999;). Class 1 integrons, gene cassettes, mobility, and epidemiology. Eur J Clin Microbiol Infect Dis 18: 761–770 [CrossRef] [PubMed].
    [Google Scholar]
  62. Forsberg K.J. , Reyes A. , Wang B. , Selleck E.M. , Sommer M.O. , Dantas G. . ( 2012;). The shared antibiotic resistome of soil bacteria and human pathogens. Science 337: 1107–1111 [CrossRef] [PubMed].
    [Google Scholar]
  63. Frank T. , Gautier V. , Talarmin A. , Bercion R. , Arlet G. . ( 2007;). Characterization of sulphonamide resistance genes and class 1 integron gene cassettes in Enterobacteriaceae, Central African Republic (CAR). J Antimicrob Chemother 59: 742–745 [CrossRef] [PubMed].
    [Google Scholar]
  64. Gassama A. , Aïdara-Kane A. , Chainier D. , Denis F. , Ploy M.C. . ( 2004;). Integron-associated antibiotic resistance in enteroaggregative and enteroinvasive Escherichia coli . Microb Drug Resist 10: 27–30 [CrossRef] [PubMed].
    [Google Scholar]
  65. Gillings M.R. . ( 2013;). Evolutionary consequences of antibiotic use for the resistome, mobilome and microbial pangenome. Front Microbiol 4: 4 [CrossRef] [PubMed].
    [Google Scholar]
  66. Gillings M. , Boucher Y. , Labbate M. , Holmes A. , Krishnan S. , Holley M. , Stokes H.W. . ( 2008;). The evolution of class 1 integrons and the rise of antibiotic resistance. J Bacteriol 190: 5095–5100 [CrossRef] [PubMed].
    [Google Scholar]
  67. Gionechetti F. , Zucca P. , Gombac F. , Monti-Bragadin C. , Lagatolla C. , Tonin E. , Edalucci E. , Vitali L.A. , Dolzani L. . ( 2008;). Characterization of antimicrobial resistance and class 1 integrons in Enterobacteriaceae isolated from Mediterranean herring gulls (Larus cachinnans). Microb Drug Resist 14: 93–99 [CrossRef] [PubMed].
    [Google Scholar]
  68. Gombac F. , Riccio M.L. , Rossolini G.M. , Lagatolla C. , Tonin E. , Monti-Bragadin C. , Lavenia A. , Dolzani L. . ( 2002;). Molecular characterization of integrons in epidemiologically unrelated clinical isolates of Acinetobacter baumannii from Italian hospitals reveals a limited diversity of gene cassette arrays. Antimicrob Agents Chemother 46: 3665–3668 [CrossRef] [PubMed].
    [Google Scholar]
  69. Gonçalves A. , Igrejas G. , Radhouani H. , Santos T. , Monteiro R. , Pacheco R. , Alcaide E. , Zorrilla I. , Serra R. , other authors . ( 2013;). Detection of antibiotic resistant enterococci and Escherichia coli in free range Iberian Lynx (Lynx pardinus). Sci Total Environ 456-457: 115–119 [CrossRef] [PubMed].
    [Google Scholar]
  70. Grape M. , Farra A. , Kronvall G. , Sundström L. . ( 2005;). Integrons and gene cassettes in clinical isolates of co-trimoxazole-resistant Gram-negative bacteria. Clin Microbiol Infect 11: 185–192 [CrossRef] [PubMed].
    [Google Scholar]
  71. Gruteke P. , Goessens W. , Van Gils J. , Peerbooms P. , Lemmens-Den Toom N. , Van Santen-Verheuvel M. , Van Belkum A. , Verbrugh H. . ( 2003;). Patterns of resistance associated with integrons, the extended-spectrum β-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak. J Clin Microbiol 41: 1161–1166 [CrossRef] [PubMed].
    [Google Scholar]
  72. Gu B. , Tong M. , Zhao W. , Liu G. , Ning M. , Pan S. , Zhao W. . ( 2007;). Prevalence and characterization of class I integrons among Pseudomonas aeruginosa Acinetobacter baumannii isolates from patients in Nanjing. China. J Clin Microbiol 45: 241–243 [CrossRef] [PubMed].
    [Google Scholar]
  73. Guerin E. , Cambray G. , Sanchez-Alberola N. , Campoy S. , Erill I. , Da Re S. , Gonzalez-Zorn B. , Barbé J. , Ploy M.C. , Mazel D. . ( 2009;). The SOS response controls integron recombination. Science 324: 1034 [CrossRef] [PubMed].
    [Google Scholar]
  74. Guerra B. , Soto S. , Cal S. , Mendoza M.C. . ( 2000;). Antimicrobial resistance and spread of class 1 integrons among Salmonella serotypes. Antimicrob Agents Chemother 44: 2166–2169 [CrossRef] [PubMed].
    [Google Scholar]
  75. Guerra B. , Junker E. , Schroeter A. , Helmuth R. , Guth B.E. , Beutin L. . ( 2006;). Phenotypic and genotypic characterization of antimicrobial resistance in Escherichia coli O111 isolates. J Antimicrob Chemother 57: 1210–1214 [CrossRef] [PubMed].
    [Google Scholar]
  76. Hall R.M. , Collis C.M. . ( 1995;). Mobile gene cassettes and integrons: capture and spread of genes by site-specific recombination. Mol Microbiol 15: 593–600 [CrossRef] [PubMed].
    [Google Scholar]
  77. Hall R.M. , Collis C.M. . ( 1998;). Antibiotic resistance in gram-negative bacteria: the role of gene cassettes and integrons. Drug Resist Updat 1: 109–119 [CrossRef] [PubMed].
    [Google Scholar]
  78. Hall R.M. , Stokes H.W. . ( 1990;). The structure of a partial duplication in the integron of plasmid pDGO100. Plasmid 23: 76–79 [CrossRef] [PubMed].
    [Google Scholar]
  79. Han N. , Sheng D. , Xu H. . ( 2012;). Role of Escherichia coli strain subgroups, integrons, and integron-associated gene cassettes in dissemination of antimicrobial resistance in aquatic environments of Jinan, China. Water Sci Technol 66: 2385–2392 [CrossRef] [PubMed].
    [Google Scholar]
  80. Harrison E.M. , Paterson G.K. , Holden M.T. , Larsen J. , Stegger M. , Larsen A.R. , Petersen A. , Skov R.L. , Christensen J.M. , other authors . ( 2013;). Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC . EMBO Mol Med 5: 509–515 [CrossRef] [PubMed].
    [Google Scholar]
  81. Havlickova H. , Hradecka H. , Bernardyova I. , Rychlik I. . ( 2009;). Distribution of integrons and SGI1 among antibiotic-resistant Salmonella enterica isolates of animal origin. Vet Microbiol 133: 193–198 [CrossRef] [PubMed].
    [Google Scholar]
  82. Hedges R.W. , Datta N. , Fleming M.P. . ( 1972;). R factors conferring resistance to trimethoprim but not sulphonamides. J Gen Microbiol 73: 573–575 [CrossRef] [PubMed].
    [Google Scholar]
  83. Heikkilä E. , Skurnik M. , Sundström L. , Huovinen P. . ( 1993;). A novel dihydrofolate reductase cassette inserted in an integron borne on a Tn21-like element. Antimicrob Agents Chemother 37: 1297–1304 [CrossRef] [PubMed].
    [Google Scholar]
  84. Heir E. , Lindstedt B.A. , Leegaard T.M. , Gjernes E. , Kapperud G. . ( 2004;). Prevalence and characterization of integrons in blood culture Enterobacteriaceae and gastrointestinal Escherichia coli in Norway and reporting of a novel class 1 integron-located lincosamide resistance gene. Ann Clin Microbiol Antimicrob 3: 12 [CrossRef] [PubMed].
    [Google Scholar]
  85. Heuer H. , Smalla K. . ( 2007;). Manure and sulfadiazine synergistically increased bacterial antibiotic resistance in soil over at least two months. Environ Microbiol 9: 657–666 [CrossRef] [PubMed].
    [Google Scholar]
  86. Heuer H. , Binh C.T. , Jechalke S. , Kopmann C. , Zimmerling U. , Krögerrecklenfort E. , Ledger T. , González B. , Top E. , Smalla K. . ( 2012;). IncP-1ε plasmids are important vectors of antibiotic resistance genes in agricultural systems: diversification driven by class 1 integron gene cassettes. Front Microbiol 3: 2 [CrossRef] [PubMed].
    [Google Scholar]
  87. Hocquet D. , Llanes C. , Thouverez M. , Kulasekara H.D. , Bertrand X. , Plésiat P. , Mazel D. , Miller S.I. . ( 2012;). Evidence for induction of integron-based antibiotic resistance by the SOS response in a clinical setting. PLoS Pathog 8: e1002778 [CrossRef] [PubMed].
    [Google Scholar]
  88. Holt K.E. , Thomson N.R. , Wain J. , Phan M.D. , Nair S. , Hasan R. , Bhutta Z.A. , Quail M.A. , Norbertczak H. , other authors . ( 2007;). Multidrug-resistant Salmonella enterica serovar paratyphi A harbors IncHI1 plasmids similar to those found in serovar typhi. J Bacteriol 189: 4257–4264 [CrossRef] [PubMed].
    [Google Scholar]
  89. Hsu S.C. , Chiu T.H. , Pang J.C. , Hsuan-Yuan C.H. , Chang G.N. , Tsen H.Y. . ( 2006;). Characterisation of antimicrobial resistance patterns and class 1 integrons among Escherichia coli Salmonella enterica serovar Choleraesuis strains isolated from humans and swine in Taiwan. Int J Antimicrob Agents 27: 383–391 [CrossRef] [PubMed].
    [Google Scholar]
  90. Hu L.F. , Chang X. , Ye Y. , Wang Z.X. , Shao Y.B. , Shi W. , Li X. , Li J.B. . ( 2011;). Stenotrophomonas maltophilia resistance to trimethoprim/sulfamethoxazole mediated by acquisition of sul dfrA genes in a plasmid-mediated class 1 integron. Int J Antimicrob Agents 37: 230–234 [CrossRef] [PubMed].
    [Google Scholar]
  91. Huovinen P. , Jacoby G.A. . ( 1991;). Sequence of the PSE-1 β-lactamase gene. Antimicrob Agents Chemother 35: 2428–2430 [CrossRef] [PubMed].
    [Google Scholar]
  92. Hussein A.I. , Ahmed A.M. , Sato M. , Shimamoto T. . ( 2009;). Characterization of integrons and antimicrobial resistance genes in clinical isolates of Gram-negative bacteria from Palestinian hospitals. Microbiol Immunol 53: 595–602 [CrossRef] [PubMed].
    [Google Scholar]
  93. Huys G. , Cnockaert M. , Nemec A. , Dijkshoorn L. , Brisse S. , Vaneechoutte M. , Swings J. . ( 2005;). Repetitive-DNA-element PCR fingerprinting and antibiotic resistance of pan-European multi-resistant Acinetobacter baumannii clone III strains. J Med Microbiol 54: 851–856 [CrossRef] [PubMed].
    [Google Scholar]
  94. Ibrahim M.E. , Magzoub M.A. , Bilal N.E. , Hamid M.E. . ( 2013;). Distribution of Class I integrons and their effect on the prevalence of multi-drug resistant Escherichia coli clinical isolates from Sudan. Saudi Med J 34: 240–247 [PubMed].
    [Google Scholar]
  95. Iversen J. , Sandvang D. , Srijan A. , Cam P.D. , Dalsgaard A. . ( 2003;). Characterization of antimicrobial resistance, plasmids, and gene cassettes in Shigella spp. from patients in Vietnam. Microb Drug Resist 9: (Suppl 1), S17–S24 [CrossRef] [PubMed].
    [Google Scholar]
  96. Jones L.A. , McIver C.J. , Kim M.J. , Rawlinson W.D. , White P.A. . ( 2005;). The aadB gene cassette is associated with bla SHV genes in Klebsiella species producing extended-spectrum β-lactamases. Antimicrob Agents Chemother 49: 794–797 [CrossRef] [PubMed].
    [Google Scholar]
  97. Jové T. , Da Re S. , Denis F. , Mazel D. , Ploy M.C. . ( 2010;). Inverse correlation between promoter strength and excision activity in class 1 integrons. PLoS Genet 6: e1000793 [CrossRef] [PubMed].
    [Google Scholar]
  98. Kadlec K. , Schwarz S. . ( 2008;). Analysis and distribution of class 1 and class 2 integrons and associated gene cassettes among Escherichia coli isolates from swine, horses, cats and dogs collected in the BfT-GermVet monitoring study. J Antimicrob Chemother 62: 469–473 [CrossRef] [PubMed].
    [Google Scholar]
  99. Kadlec K. , von Czapiewski E. , Kaspar H. , Wallmann J. , Michael G.B. , Steinacker U. , Schwarz S. . ( 2011;). Molecular basis of sulfonamide and trimethoprim resistance in fish-pathogenic Aeromonas isolates. Appl Environ Microbiol 77: 7147–7150 [CrossRef] [PubMed].
    [Google Scholar]
  100. Kang H.Y. , Jeong Y.S. , Oh J.Y. , Tae S.H. , Choi C.H. , Moon D.C. , Lee W.K. , Lee Y.C. , Seol S.Y. , other authors . ( 2005;). Characterization of antimicrobial resistance and class 1 integrons found in Escherichia coli isolates from humans and animals in Korea. J Antimicrob Chemother 55: 639–644 [CrossRef] [PubMed].
    [Google Scholar]
  101. Kang M.S. , Kim A. , Jung B.Y. , Her M. , Jeong W. , Cho Y.M. , Oh J.Y. , Lee Y.J. , Kwon J.H. , Kwon Y.K. . ( 2010;). Characterization of antimicrobial resistance of recent Salmonella enterica serovar Gallinarum isolates from chickens in South Korea. Avian Pathol 39: 201–205 [CrossRef] [PubMed].
    [Google Scholar]
  102. Kansakar P. , Dorji D. , Chongtrakool P. , Mingmongkolchai S. , Mokmake B. , Dubbs P. . ( 2011;). Local dissemination of multidrug-resistant Acinetobacter baumannii clones in a Thai hospital. Microb Drug Resist 17: 109–119 [CrossRef] [PubMed].
    [Google Scholar]
  103. Karczmarczyk M. , Abbott Y. , Walsh C. , Leonard N. , Fanning S. . ( 2011;). Characterization of multidrug-resistant Escherichia coli isolates from animals presenting at a university veterinary hospital. Appl Environ Microbiol 77: 7104–7112 [CrossRef] [PubMed].
    [Google Scholar]
  104. Kazama H. , Kizu K. , Iwasaki M. , Hamashima H. , Sasatsu M. , Arai T. . ( 1995;). Isolation and structure of a new integron that includes a streptomycin resistance gene from the R plasmid of Pseudomonas aeruginosa . FEMS Microbiol Lett 134: 137–141 [CrossRef] [PubMed].
    [Google Scholar]
  105. Khan A.A. , Cheng C.M. , Van K.T. , West C.S. , Nawaz M.S. , Khan S.A. . ( 2006;). Characterization of class 1 integron resistance gene cassettes in Salmonella enterica serovars Oslo and Bareily from imported seafood. J Antimicrob Chemother 58: 1308–1310 [CrossRef] [PubMed].
    [Google Scholar]
  106. Khemtong S. , Chuanchuen R. . ( 2008;). Class 1 integrons and Salmonella genomic island 1 among Salmonella enterica isolated from poultry and swine. Microb Drug Resist 14: 65–70 [CrossRef] [PubMed].
    [Google Scholar]
  107. Kiiru J. , Butaye P. , Goddeeris B.M. , Kariuki S. . ( 2013;). Analysis for prevalence and physical linkages amongst integrons, ISEcp1, ISCR1, Tn21 and Tn7 encountered in Escherichia coli strains from hospitalized and non-hospitalized patients in Kenya during a 19-year period (1992–2011). BMC Microbiol 13: 109 [CrossRef] [PubMed].
    [Google Scholar]
  108. Kikuvi G.M. , Schwarz S. , Ombui J.N. , Mitema E.S. , Kehrenberg C. . ( 2007;). Streptomycin and chloramphenicol resistance genes in Escherichia coli isolates from cattle, pigs, and chicken in Kenya. Microb Drug Resist 13: 62–68 [CrossRef] [PubMed].
    [Google Scholar]
  109. Kim S. , Kim S.H. , Kim J. , Shin J.H. , Lee B.K. , Park M.S. . ( 2011;). Occurrence and distribution of various genetic structures of class 1 and class 2 integrons in Salmonella enterica isolates from foodborne disease patients in Korea for 16 years. Foodborne Pathog Dis 8: 319–324 [CrossRef] [PubMed].
    [Google Scholar]
  110. Koczura R. , Mokracka J. , Krzymińska S. , Kaznowski A. . ( 2011;). Virulence properties and integron-associated antibiotic resistance of Klebsiella mobilis strains isolated from clinical specimens. J Med Microbiol 60: 281–288 [CrossRef] [PubMed].
    [Google Scholar]
  111. Koh T.H. , Sng L.H. , Wang G.C. , Hsu L.Y. , Zhao Y. . ( 2007;). IMP-4 and OXA β-lactamases in Acinetobacter baumannii from Singapore. J Antimicrob Chemother 59: 627–632 [CrossRef] [PubMed].
    [Google Scholar]
  112. Kor S.B. , Choo Q.C. , Chew C.H. . ( 2013;). New integron gene arrays from multiresistant clinical isolates of members of the Enterobacteriaceae Pseudomonas aeruginosa from hospitals in Malaysia. J Med Microbiol 62: 412–420 [CrossRef] [PubMed].
    [Google Scholar]
  113. Kouda S. , Ohara M. , Onodera M. , Fujiue Y. , Sasaki M. , Kohara T. , Kashiyama S. , Hayashida S. , Harino T. , other authors . ( 2009;). Increased prevalence and clonal dissemination of multidrug-resistant Pseudomonas aeruginosa with the bla IMP-1 gene cassette in Hiroshima. J Antimicrob Chemother 64: 46–51 [CrossRef] [PubMed].
    [Google Scholar]
  114. Krauland M.G. , Marsh J.W. , Paterson D.L. , Harrison L.H. . ( 2009;). Integron-mediated multidrug resistance in a global collection of nontyphoidal Salmonella enterica isolates. Emerg Infect Dis 15: 388–396 [CrossRef] [PubMed].
    [Google Scholar]
  115. Kumai Y. , Suzuki Y. , Tanaka Y. , Shima K. , Bhadra R.K. , Yamasaki S. , Kuroda K. , Endo G. . ( 2005;). Characterization of multidrug-resistance phenotypes and genotypes of Escherichia coli strains isolated from swine from an abattoir in Osaka, Japan. Epidemiol Infect 133: 59–70 [CrossRef] [PubMed].
    [Google Scholar]
  116. L'Abée-Lund T.M. , Sorum H. . ( 2001;). Class 1 integrons mediate antibiotic resistance in the fish pathogen Aeromonas salmonicida worldwide. Microb Drug Resist 7: 263–272 [CrossRef] [PubMed].
    [Google Scholar]
  117. Labar A.S. , Millman J.S. , Ruebush E. , Opintan J.A. , Bishar R.A. , Aboderin A.O. , Newman M.J. , Lamikanra A. , Okeke I.N. . ( 2012;). Regional dissemination of a trimethoprim-resistance gene cassette via a successful transposable element. PLoS One 7: e38142 [CrossRef] [PubMed].
    [Google Scholar]
  118. Lapierre L. , Cornejo J. , Borie C. , Toro C. , San Martín B. . ( 2008;). Genetic characterization of antibiotic resistance genes linked to class 1 and class 2 integrons in commensal strains of Escherichia coli isolated from poultry and swine. Microb Drug Resist 14: 265–272 [CrossRef] [PubMed].
    [Google Scholar]
  119. Lay K.K. , Koowattananukul C. , Chansong N. , Chuanchuen R. . ( 2012;). Antimicrobial resistance, virulence, and phylogenetic characteristics of Escherichia coli isolates from clinically healthy swine. Foodborne Pathog Dis 9: 992–1001 [CrossRef] [PubMed].
    [Google Scholar]
  120. Lee K.E. , Lee Y. . ( 2007;). Isolation of multidrug-resistant Salmonella typhimurium DT104 from swine in Korea. J Microbiol 45: 590–592 [PubMed].
    [Google Scholar]
  121. Lee K. , Yong D. , Yum J.H. , Lim Y.S. , Kim H.S. , Lee B.K. , Chong Y. . ( 2004;). Emergence of multidrug-resistant Salmonella enterica serovar typhi in Korea. Antimicrob Agents Chemother 48: 4130–4135 [CrossRef] [PubMed].
    [Google Scholar]
  122. Lee M.F. , Peng C.F. , Lin Y.H. , Lin S.R. , Chen Y.H. . ( 2008;). Molecular diversity of class 1 integrons in human isolates of Aeromonas spp. from southern Taiwan. Jpn J Infect Dis 61: 343–349 [PubMed].
    [Google Scholar]
  123. Lee M.F. , Chen Y.H. , Peng C.F. . ( 2009;). Molecular characterisation of class 1 integrons in Salmonella enterica serovar Choleraesuis isolates from southern Taiwan. Int J Antimicrob Agents 33: 216–222 [CrossRef] [PubMed].
    [Google Scholar]
  124. Lévesque R.C. , Jacoby G.A. . ( 1988;). Molecular structure and interrelationships of multiresistance β-lactamase transposons. Plasmid 19: 21–29 [CrossRef] [PubMed].
    [Google Scholar]
  125. Lévesque C. , Piché L. , Larose C. , Roy P.H. . ( 1995;). PCR mapping of integrons reveals several novel combinations of resistance genes. Antimicrob Agents Chemother 39: 185–191 [CrossRef] [PubMed].
    [Google Scholar]
  126. Li Q. , Skyberg J.A. , Fakhr M.K. , Sherwood J.S. , Nolan L.K. , Logue C.M. . ( 2006;). Antimicrobial susceptibility and characterization of Salmonella isolates from processed bison carcasses. Appl Environ Microbiol 72: 3046–3049 [CrossRef] [PubMed].
    [Google Scholar]
  127. Li D. , Yang M. , Hu J. , Zhang J. , Liu R. , Gu X. , Zhang Y. , Wang Z. . ( 2009;). Antibiotic-resistance profile in environmental bacteria isolated from penicillin production wastewater treatment plant and the receiving river. Environ Microbiol 11: 1506–1517 [CrossRef] [PubMed].
    [Google Scholar]
  128. Li D. , Yu T. , Zhang Y. , Yang M. , Li Z. , Liu M. , Qi R. . ( 2010;). Antibiotic resistance characteristics of environmental bacteria from an oxytetracycline production wastewater treatment plant and the receiving river. Appl Environ Microbiol 76: 3444–3451 [CrossRef] [PubMed].
    [Google Scholar]
  129. Libisch B. , Balogh B. , Füzi M. . ( 2009;). Identification of two multidrug-resistant Pseudomonas aeruginosa clonal lineages with a countrywide distribution in Hungary. Curr Microbiol 58: 111–116 [CrossRef] [PubMed].
    [Google Scholar]
  130. Liebert C.A. , Hall R.M. , Summers A.O. . ( 1999;). Transposon Tn21, flagship of the floating genome. Microbiol Mol Biol Rev 63: 507–522 [PubMed].
    [Google Scholar]
  131. Lindstedt B.A. , Heir E. , Nygård I. , Kapperud G. . ( 2003;). Characterization of class I integrons in clinical strains of Salmonella enterica subsp. enterica serovars Typhimurium and Enteritidis from Norwegian hospitals. J Med Microbiol 52: 141–149 [CrossRef] [PubMed].
    [Google Scholar]
  132. Lu L. , Dai L. , Wang Y. , Wu C. , Chen X. , Li L. , Qi Y. , Xia L. , Shen J. . ( 2010;). Characterization of antimicrobial resistance and integrons among Escherichia coli isolated from animal farms in Eastern China. Acta Trop 113: 20–25 [CrossRef] [PubMed].
    [Google Scholar]
  133. Lukkana M. , Wongtavatchai J. , Chuanchuen R. . ( 2012;). Class 1 integrons in Aeromonas hydrophila isolates from farmed Nile tilapia (Oreochromis nilotica). J Vet Med Sci 74: 435–440 [CrossRef] [PubMed].
    [Google Scholar]
  134. Machado E. , Coque T.M. , Cantón R. , Sousa J.C. , Peixe L. . ( 2008;). Antibiotic resistance integrons and extended-spectrum β-lactamases among Enterobacteriaceae isolates recovered from chickens and swine in Portugal. J Antimicrob Chemother 62: 296–302 [CrossRef] [PubMed].
    [Google Scholar]
  135. Mahrouki S. , Belhadj O. , Chihi H. , Mohamed B.M. , Celenza G. , Amicosante G. , Perilli M. . ( 2012;). Chromosomal bla CTX-M-15 associated with ISEcp1 in Proteus mirabilis Morganella morganii isolated at the Military Hospital of Tunis, Tunisia. J Med Microbiol 61: 1286–1289 [CrossRef] [PubMed].
    [Google Scholar]
  136. Majtan T. , Majtanova L. , Timko J. , Majtan V. . ( 2007;). Oligonucleotide microarray for molecular characterization and genotyping of Salmonella spp. strains. J Antimicrob Chemother 60: 937–946 [CrossRef] [PubMed].
    [Google Scholar]
  137. Matthew M. , Sykes R.B. . ( 1977;). Properties of the β-lactamase specified by the Pseudomonas plasmid RPL11. J Bacteriol 132: 341–345 [PubMed].
    [Google Scholar]
  138. Mazel D. . ( 2006;). Integrons: agents of bacterial evolution. Nat Rev Microbiol 4: 608–620 101038/nrmicro1462 [PubMed].[CrossRef]
    [Google Scholar]
  139. Mokracka J. , Koczura R. , Pawlowski K. , Kaznowski A. . ( 2011;). Resistance patterns and integron cassette arrays of Enterobacter cloacae complex strains of human origin. J Med Microbiol 60: 737–743 [CrossRef] [PubMed].
    [Google Scholar]
  140. Mokracka J. , Koczura R. , Kaznowski A. . ( 2012;). Multiresistant Enterobacteriaceae with class 1 and class 2 integrons in a municipal wastewater treatment plant. Water Res 46: 3353–3363 [CrossRef] [PubMed].
    [Google Scholar]
  141. Molla B. , Miko A. , Pries K. , Hildebrandt G. , Kleer J. , Schroeter A. , Helmuth R. . ( 2007;). Class 1 integrons and resistance gene cassettes among multidrug resistant Salmonella serovars isolated from slaughter animals and foods of animal origin in Ethiopia. Acta Trop 103: 142–149 [CrossRef] [PubMed].
    [Google Scholar]
  142. Morabito S. , Tozzoli R. , Caprioli A. , Karch H. , Carattoli A. . ( 2002;). Detection and characterization of class 1 integrons in enterohemorrhagic Escherichia coli . Microb Drug Resist 8: 85–91 [CrossRef] [PubMed].
    [Google Scholar]
  143. Moura A. , Henriques I. , Ribeiro R. , Correia A. . ( 2007;). Prevalence and characterization of integrons from bacteria isolated from a slaughterhouse wastewater treatment plant. J Antimicrob Chemother 60: 1243–1250 [CrossRef] [PubMed].
    [Google Scholar]
  144. Moura A. , Soares M. , Pereira C. , Leitão N. , Henriques I. , Correia A. . ( 2009;). integrall: a database and search engine for integrons, integrases and gene cassettes. Bioinformatics 25: 1096–1098 [CrossRef] [PubMed].
    [Google Scholar]
  145. Moura A. , Pereira C. , Henriques I. , Correia A. . ( 2012;). Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters. Res Microbiol 163: 92–100 [CrossRef] [PubMed].
    [Google Scholar]
  146. Mukherjee S. , Chakraborty R. . ( 2006;). Incidence of class 1 integrons in multiple antibiotic-resistant Gram-negative copiotrophic bacteria from the River Torsa in India. Res Microbiol 157: 220–226 [CrossRef] [PubMed].
    [Google Scholar]
  147. Murphy B.P. , O'Mahony R. , Buckley J.F. , Shine P. , Boyd E.F. , Gilroy D. , Fanning S. . ( 2007;). Investigation of a global collection of nontyphoidal Salmonella of various serotypes cultured between 1953 and 2004 for the presence of class 1 integrons. FEMS Microbiol Lett 266: 170–176 [CrossRef] [PubMed].
    [Google Scholar]
  148. Najibi S. , Bakhshi B. , Fallahzad S. , Pourshafie M.R. , Katouli M. , Sattari M. , Alebouyeh M. , Tajbakhsh M. . ( 2012;). Distribution of class 1 integrons among enteropathogenic Escherichia coli . Can J Microbiol 58: 637–643 [CrossRef] [PubMed].
    [Google Scholar]
  149. Nakaya R. , Nakamura A. , Murata Y. . ( 1960;). Resistance transfer agents in Shigella . Biochem Biophys Res Commun 3: 654–659 [CrossRef] [PubMed].
    [Google Scholar]
  150. Nardelli M. , Scalzo P.M. , Ramírez M.S. , Quiroga M.P. , Cassini M.H. , Centrón D. . ( 2012;). Class 1 integrons in environments with different degrees of urbanization. PLoS One 7: e39223 [CrossRef] [PubMed].
    [Google Scholar]
  151. Navia M.M. , Ruiz J. , Vila J. . ( 2004;). Molecular characterization of the integrons in Shigella strains isolated from patients with traveler's diarrhea. Diagn Microbiol Infect Dis 48: 175–179 [CrossRef] [PubMed].
    [Google Scholar]
  152. Ndi O.L. , Barton M.D. . ( 2011;). Incidence of class 1 integron and other antibiotic resistance determinants in Aeromonas spp. from rainbow trout farms in Australia. J Fish Dis 34: 589–599 [CrossRef] [PubMed].
    [Google Scholar]
  153. Nemec A. , Dolzani L. , Brisse S. , van den Broek P. , Dijkshoorn L. . ( 2004;). Diversity of aminoglycoside-resistance genes and their association with class 1 integrons among strains of pan-European Acinetobacter baumannii clones. J Med Microbiol 53: 1233–1240 [CrossRef] [PubMed].
    [Google Scholar]
  154. Nesvera J. , Hochmannová J. , Pátek M. . ( 1998;). An integron of class 1 is present on the plasmid pCG4 from Gram-positive bacterium Corynebacterium glutamicum . FEMS Microbiol Lett 169: 391–395 [CrossRef] [PubMed].
    [Google Scholar]
  155. Ng L.K. , Mulvey M.R. , Martin I. , Peters G.A. , Johnson W. . ( 1999;). Genetic characterization of antimicrobial resistance in Canadian isolates of Salmonella serovar Typhimurium DT104. Antimicrob Agents Chemother 43: 3018–3021 [PubMed].
    [Google Scholar]
  156. Nógrády N. , Gadó I. , Tóth A. , Pászti J. . ( 2005;). Antibiotic resistance and class 1 integron patterns of non-typhoidal human Salmonella serotypes isolated in Hungary in 2002 and 2003. Int J Antimicrob Agents 26: 126–132 [CrossRef] [PubMed].
    [Google Scholar]
  157. Nógrády N. , Király M. , Borbás K. , Tóth A. , Pászti J. , Tóth I. . ( 2013;). Antimicrobial resistance and genetic characteristics of integron-carrier shigellae isolated in Hungary; 1998–2008. J Med Microbiol 62: 1545–1551.[CrossRef]
    [Google Scholar]
  158. O'Halloran F. , Lucey B. , Cryan B. , Buckley T. , Fanning S. . ( 2004;). Molecular characterization of class 1 integrons from Irish thermophilic Campylobacter spp. J Antimicrob Chemother 53: 952–957 [CrossRef] [PubMed].
    [Google Scholar]
  159. Ozgumus O.B. , Celik-Sevim E. , Alpay-Karaoglu S. , Sandalli C. , Sevim A. . ( 2007;). Molecular characterization of antibiotic resistant Escherichia coli strains isolated from tap and spring waters in a coastal region in Turkey. J Microbiol 45: 379–387 [PubMed].
    [Google Scholar]
  160. Ozgumus O.B. , Sandalli C. , Sevim A. , Celik-Sevim E. , Sivri N. . ( 2009;). Class 1 and class 2 integrons and plasmid-mediated antibiotic resistance in coliforms isolated from ten rivers in northern Turkey. J Microbiol 47: 19–27 [CrossRef] [PubMed].
    [Google Scholar]
  161. Pallecchi L. , Lucchetti C. , Bartoloni A. , Bartalesi F. , Mantella A. , Gamboa H. , Carattoli A. , Paradisi F. , Rossolini G.M. . ( 2007;). Population structure and resistance genes in antibiotic-resistant bacteria from a remote community with minimal antibiotic exposure. Antimicrob Agents Chemother 51: 1179–1184 [CrossRef] [PubMed].
    [Google Scholar]
  162. Pan J.C. , Ye R. , Meng D.M. , Zhang W. , Wang H.Q. , Liu K.Z. . ( 2006;). Molecular characteristics of class 1 and class 2 integrons and their relationships to antibiotic resistance in clinical isolates of Shigella sonnei Shigella flexneri . J Antimicrob Chemother 58: 288–296 [CrossRef] [PubMed].
    [Google Scholar]
  163. Partridge S.R. , Hall R.M. . ( 2005;). [CrossRef] [PubMed] Correctly identifying the streptothricin resistance gene cassette. J Clin Microbiol 43: 4298–4300.
    [Google Scholar]
  164. Partridge S.R. , Brown H.J. , Stokes H.W. , Hall R.M. . ( 2001;). Transposons Tn1696 and Tn21 and their integrons In4 and In2 have independent origins. Antimicrob Agents Chemother 45: 1263–1270 [CrossRef] [PubMed].
    [Google Scholar]
  165. Partridge S.R. , Brown H.J. , Hall R.M. . ( 2002;). Characterization and movement of the class 1 integron known as Tn2521 and Tn1405 . Antimicrob Agents Chemother 46: 1288–1294 [CrossRef] [PubMed].
    [Google Scholar]
  166. Partridge S.R. , Tsafnat G. , Coiera E. , Iredell J.R. . ( 2009;). Gene cassettes and cassette arrays in mobile resistance integrons. FEMS Microbiol Rev 33: 757–784 [CrossRef] [PubMed].
    [Google Scholar]
  167. Pazhani G.P. , Chakraborty S. , Fujihara K. , Yamasaki S. , Ghosh A. , Nair G.B. , Ramamurthy T. . ( 2011;). QRDR mutations, efflux system & antimicrobial resistance genes in enterotoxigenic Escherichia coli isolated from an outbreak of diarrhoea in Ahmedabad, India. Indian J Med Res 134: 214–223 [PubMed].
    [Google Scholar]
  168. Peirano G. , Agersø Y. , Aarestrup F.M. , dos Prazeres Rodrigues D. . ( 2006;). [CrossRef] [PubMed] Occurrence of integrons and antimicrobial resistance genes among Salmonella enterica from Brazil. J Antimicrob Chemother 305–309:.
    [Google Scholar]
  169. Pellegrini C. , Mercuri P.S. , Celenza G. , Galleni M. , Segatore B. , Sacchetti E. , Volpe R. , Amicosante G. , Perilli M. . ( 2009;). Identification of bla IMP-22 in Pseudomonas spp. in urban wastewater and nosocomial environments: biochemical characterization of a new IMP metallo-enzyme variant and its genetic location. J Antimicrob Chemother 63: 901–908 [CrossRef] [PubMed].
    [Google Scholar]
  170. Peng C.F. , Lee M.F. , Fu H.T. , Chen Y.J. , Hsu H.J. . ( 2007;). Characterization of class 1 integrons and antimicrobial resistance in CTX-M-3-producing Serratia marcescens isolates from southern Taiwan. Jpn J Infect Dis 60: 250–256 [PubMed].
    [Google Scholar]
  171. Pepperell C. , Kus J.V. , Gardam M.A. , Humar A. , Burrows L.L. . ( 2002;). Low-virulence Citrobacter species encode resistance to multiple antimicrobials. Antimicrob Agents Chemother 46: 3555–3560 [CrossRef] [PubMed].
    [Google Scholar]
  172. Pérez-Moreno M.O. , Picó-Plana E. , de Toro M. , Grande-Armas J. , Quiles-Fortuny V. , Pons M.J. , Gomes C. , Sáenz Y. , Torres C. , Ruiz J.β-L. . ( 2013;). Lactamases, transferable quinolone resistance determinants, and class 1 integron-mediated antimicrobial resistance in human clinical Salmonella enterica isolates of non-Typhimurium serotypes. Int J Med Microbiol 303: 25–31 [CrossRef] [PubMed].
    [Google Scholar]
  173. Pérez-Valdespino A. , Fernández-Rendón E. , Curiel-Quesada E. . ( 2009;). Detection and characterization of class 1 integrons in Aeromonas spp. isolated from human diarrheic stool in Mexico. J Basic Microbiol 49: 572–578 [CrossRef] [PubMed].
    [Google Scholar]
  174. Peters E.D. , Leverstein-van Hall M.A. , Box A.T. , Verhoef J. , Fluit A.C. . ( 2001;). Novel gene cassettes and integrons. Antimicrob Agents Chemother 45: 2961–2964 [CrossRef] [PubMed].
    [Google Scholar]
  175. Petrova M. , Gorlenko Z. , Mindlin S. . ( 2011;). Tn5045, a novel integron-containing antibiotic and chromate resistance transposon isolated from a permafrost bacterium. Res Microbiol 162: 337–345 [CrossRef] [PubMed].
    [Google Scholar]
  176. Plante I. , Centrón D. , Roy P.H. . ( 2003;). Direct sequencing and PCR mapping of integrons reveals multiple class 1 integrons in the multiresistant strain Enterobacter cloacae SCH88040794. FEMS Microbiol Lett 221: 59–62 [CrossRef] [PubMed].
    [Google Scholar]
  177. Ploy M.C. , Chainier D. , Tran Thi N.H. , Poilane I. , Cruaud P. , Denis F. , Collignon A. , Lambert T. . ( 2003;). Integron-associated antibiotic resistance in Salmonella enterica serovar typhi from Asia. Antimicrob Agents Chemother 47: 1427–1429 [CrossRef] [PubMed].
    [Google Scholar]
  178. Poirel L. , Guibert M. , Bellais S. , Naas T. , Nordmann P. . ( 1999;). Integron- and carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype typhimurium DT104 from French patients. Antimicrob Agents Chemother 43: 1098–1104 [PubMed].
    [Google Scholar]
  179. Povilonis J. , Šeputiene˙ V. , Ružauskas M. , Šiugždiniene˙ R. , Virgailis M. , Pavilonis A. , Sužiede˙liene˙ E. . ( 2010;). Transferable class 1 and 2 integrons in Escherichia coli Salmonella enterica isolates of human and animal origin in Lithuania. Foodborne Pathog Dis 7: 1185–1192 [CrossRef] [PubMed].
    [Google Scholar]
  180. Power M.L. , Emery S. , Gillings M.R. . ( 2013;). Into the wild: dissemination of antibiotic resistance determinants via a species recovery program. PLoS One 8: e63017 [CrossRef] [PubMed].
    [Google Scholar]
  181. Rajpara N. , Patel A. , Tiwari N. , Bahuguna J. , Antony A. , Choudhury I. , Ghosh A. , Jain R. , Ghosh A. , Bhardwaj A.K. . ( 2009;). Mechanism of drug resistance in a clinical isolate of Vibrio fluvialis: involvement of multiple plasmids and integrons. Int J Antimicrob Agents 34: 220–225 [CrossRef] [PubMed].
    [Google Scholar]
  182. Rakotonirina H.C. , Garin B. , Randrianirina F. , Richard V. , Talarmin A. , Arlet G. . ( 2013;). Molecular characterization of multidrug-resistant extended-spectrum β-lactamase-producing Enterobacteriaceae isolated in Antananarivo, Madagascar. BMC Microbiol 13: 85 [CrossRef] [PubMed].
    [Google Scholar]
  183. Ramirez M.S. , Tolmasky M.E. . ( 2010;). Aminoglycoside modifying enzymes. Drug Resist Updat 13: 151–171 [CrossRef] [PubMed].
    [Google Scholar]
  184. Ranjbar R. , Giammanco G.M. , Farshad S. , Owlia P. , Aleo A. , Mammina C. . ( 2011;). Serotypes, antibiotic resistance, and class 1 integrons in Salmonella isolates from pediatric cases of enteritis in Tehran, Iran. Foodborne Pathog Dis 8: 547–553 [CrossRef] [PubMed].
    [Google Scholar]
  185. Recchia G.D. , Hall R.M. . ( 1995;). Gene cassettes: a new class of mobile element. Microbiology 141: 3015–3027 [CrossRef] [PubMed].
    [Google Scholar]
  186. Ridley A. , Threlfall E.J. . ( 1998;). Molecular epidemiology of antibiotic resistance genes in multiresistant epidemic Salmonella typhimurium DT 104. Microb Drug Resist 4: 113–118 [CrossRef] [PubMed].
    [Google Scholar]
  187. Roberts M.C. , Schwarz S. , Aarts H.J. . ( 2012;). Erratum: Acquired antibiotic resistance genes: an overview. Front Microbiol 3: 384 [CrossRef] [PubMed].
    [Google Scholar]
  188. Rodríguez I. , Martín M.C. , Mendoza M.C. , Rodicio M.R. . ( 2006;). Class 1 and class 2 integrons in non-prevalent serovars of Salmonella enterica: structure and association with transposons and plasmids. J Antimicrob Chemother 58: 1124–1132 [CrossRef] [PubMed].
    [Google Scholar]
  189. Rodríguez I. , Barownick W. , Helmuth R. , Mendoza M.C. , Rodicio M.R. , Schroeter A. , Guerra B. . ( 2009;). Extended-spectrum β-lactamases and AmpC β-lactamases in ceftiofur-resistant Salmonella enterica isolates from food and livestock obtained in Germany during 2003–07. J Antimicrob Chemother 64: 301–309 [CrossRef] [PubMed].
    [Google Scholar]
  190. Rodríguez M.M. , Power P. , Sader H. , Galleni M. , Gutkind G. . ( 2010;). Novel chromosome-encoded CTX-M-78 β-lactamase from a Kluyvera georgiana clinical isolate as a putative origin of CTX-M-25 subgroup. Antimicrob Agents Chemother 54: 3070–3071 [CrossRef] [PubMed].
    [Google Scholar]
  191. Rosser S.J. , Young H.K. . ( 1999;). Identification and characterization of class 1 integrons in bacteria from an aquatic environment. J Antimicrob Chemother 44: 11–18 [CrossRef] [PubMed].
    [Google Scholar]
  192. Rowe-Magnus D.A. , Guerout A.M. , Ploncard P. , Dychinco B. , Davies J. , Mazel D. . ( 2001;). The evolutionary history of chromosomal super-integrons provides an ancestry for multiresistant integrons. Proc Natl Acad Sci U S A 98: 652–657 [CrossRef] [PubMed].
    [Google Scholar]
  193. Rowe-Magnus D.A. , Guerout A.M. , Mazel D. . ( 2002;). Bacterial resistance evolution by recruitment of super-integron gene cassettes. Mol Microbiol 43: 1657–1669 [CrossRef] [PubMed].
    [Google Scholar]
  194. Ruiz-Martínez L. , López-Jiménez L. , Fusté E. , Vinuésa T. , Martínez J.P. , Viñas M. . ( 2011;). Class 1 integrons in environmental and clinical isolates of Pseudomonas aeruginosa . Int J Antimicrob Agents 38: 398–402 [CrossRef] [PubMed].
    [Google Scholar]
  195. L.L. , Fonseca E.L. , Pellegrini M. , Freitas F. , Loureiro E.C. , Vicente A.C. . ( 2010;). Occurrence and composition of class 1 and class 2 integrons in clinical and environmental O1 and non-O1/non-O139 Vibrio cholerae strains from the Brazilian Amazon. Mem Inst Oswaldo Cruz 105: 229–232 [CrossRef] [PubMed].
    [Google Scholar]
  196. Sandalli C. , Buruk C.K. , Sancaktar M. , Ozgumus O.B. . ( 2010;). Prevalence of integrons and a new dfrA17 variant in Gram-negative bacilli which cause community-acquired infections. Microbiol Immunol 54: 164–169 [CrossRef] [PubMed].
    [Google Scholar]
  197. Sandvang D. . ( 1999;). Novel streptomycin and spectinomycin resistance gene as a gene cassette within a class 1 integron isolated from Escherichia coli . Antimicrob Agents Chemother 43: 3036–3038 [PubMed].
    [Google Scholar]
  198. Sandvang D. , Aarestrup F.M. . ( 2000;). Characterization of aminoglycoside resistance genes and class 1 integrons in porcine and bovine gentamicin-resistant Escherichia coli . Microb Drug Resist 6: 19–27 [PubMed].[CrossRef]
    [Google Scholar]
  199. Sandvang D. , Aarestrup F.M. , Jensen L.B. . ( 1998;). Characterisation of integrons and antibiotic resistance genes in Danish multiresistant Salmonella enterica Typhimurium DT104. FEMS Microbiol Lett 160: 37–41 [CrossRef] [PubMed].
    [Google Scholar]
  200. Segal H. , Thomas R. , Gay Elisha B. . ( 2003;). Characterization of class 1 integron resistance gene cassettes and the identification of a novel IS-like element in Acinetobacter baumannii . Plasmid 49: 169–178 [CrossRef] [PubMed].
    [Google Scholar]
  201. Shahcheraghi F. , Badmasti F. , Feizabadi M.M. . ( 2010;). Molecular characterization of class 1 integrons in MDR Pseudomonas aeruginosa isolated from clinical settings in Iran, Tehran. FEMS Immunol Med Microbiol 58: 421–425 [PubMed].
    [Google Scholar]
  202. Shaw K.J. , Rather P.N. , Hare R.S. , Miller G.H. . ( 1993;). Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol Rev 57: 138–163 [PubMed].
    [Google Scholar]
  203. Shi L. , Zheng M. , Xiao Z. , Asakura M. , Su J. , Li L. , Yamasaki S. . ( 2006a;). Unnoticed spread of class 1 integrons in gram-positive clinical strains isolated in Guangzhou, China. Microbiol Immunol 50: 463–467 [CrossRef] [PubMed].
    [Google Scholar]
  204. Shi L. , Fujihara K. , Sato T. , Ito H. , Garg P. , Chakrabarty R. , Ramamurthy T. , Nair G.B. , Takeda Y. , Yamasaki S. . ( 2006b;). Distribution and characterization of integrons in various serogroups of Vibrio cholerae strains isolated from diarrhoeal patients between 1992 and 2000 in Kolkata, India. J Med Microbiol 55: 575–583 [CrossRef] [PubMed].
    [Google Scholar]
  205. Shin G.W. , You M.J. , Lee H.S. , Lee C.S. . ( 2012;). Catheter-related bacteremia caused by multidrug-resistant Leclercia adecarboxylata in a patient with breast cancer. J Clin Microbiol 50: 3129–3132 [CrossRef] [PubMed].
    [Google Scholar]
  206. Sidjabat H.E. , Townsend K.M. , Lorentzen M. , Gobius K.S. , Fegan N. , Chin J.J. , Bettelheim K.A. , Hanson N.D. , Bensink J.C. , Trott D.J. . ( 2006;). Emergence and spread of two distinct clonal groups of multidrug-resistant Escherichia coli in a veterinary teaching hospital in Australia. J Med Microbiol 55: 1125–1134 [CrossRef] [PubMed].
    [Google Scholar]
  207. Sivri N. , Sandalli C. , Ozgumus O.B. , Colakoglu F. , Dogan D. . ( 2012;). Antibiotic resistance profiles of enteric bacteria isolated from Kucukcekmece Lagoon (Istanbul–Turkey). Turk J Fish Aquat Sci 12: 699–707 [CrossRef].
    [Google Scholar]
  208. Solberg O.D. , Ajiboye R.M. , Riley L.W. . ( 2006;). Origin of class 1 and 2 integrons and gene cassettes in a population-based sample of uropathogenic Escherichia coli . J Clin Microbiol 44: 1347–1351 [CrossRef] [PubMed].
    [Google Scholar]
  209. Soufi L. , Sáenz Y. , de Toro M. , Abbassi M.S. , Rojo-Bezares B. , Vinué L. , Bouchami O. , Touati A. , Ben Hassen A. , other authors . ( 2012;). Phenotypic and genotypic characterization of Salmonella enterica recovered from poultry meat in Tunisia and identification of new genetic traits. Vector Borne Zoonotic Dis 12: 10–16 [CrossRef] [PubMed].
    [Google Scholar]
  210. Sow A.G. , Wane A.A. , Diallo M.H. , Boye C.S. , Aïdara-Kane A. . ( 2007;). Genotypic characterization of antibiotic-resistant Salmonella enteritidis isolates in Dakar, Senegal. J Infect Dev Ctries 1: 284–288 [PubMed].
    [Google Scholar]
  211. Srinivasan V.B. , Virk R.K. , Kaundal A. , Chakraborty R. , Datta B. , Ramamurthy T. , Mukhopadhyay A.K. , Ghosh A. . ( 2006;). Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India. Antimicrob Agents Chemother 50: 2428–2432 [CrossRef] [PubMed].
    [Google Scholar]
  212. Srinivasan V. , Nam H.M. , Sawant A.A. , Headrick S.I. , Nguyen L.T. , Oliver S.P. . ( 2008;). Distribution of tetracycline and streptomycin resistance genes and class 1 integrons in Enterobacteriaceae isolated from dairy and nondairy farm soils. Microb Ecol 55: 184–193 [CrossRef] [PubMed].
    [Google Scholar]
  213. Stalder T. , Barraud O. , Jové T. , Casellas M. , Gaschet M. , Dagot C. , Ploy M.C. . ( 2014;). Quantitative and qualitative impact of hospital effluent on dissemination of the integron pool. ISME J 8: 768–777 [CrossRef] [PubMed].
    [Google Scholar]
  214. Starikova I. , Harms K. , Haugen P. , Lunde T.T.M. , Primicerio R. , Samuelsen Ø. , Nielsen K.M. , Johnsen P.J. . ( 2012;). A trade-off between the fitness cost of functional integrases and long-term stability of integrons. PLoS Pathog 8: e1003043 [CrossRef] [PubMed].
    [Google Scholar]
  215. Stokes H.W. , Gillings M.R. . ( 2011;). Gene flow, mobile genetic elements and the recruitment of antibiotic resistance genes into Gram-negative pathogens. FEMS Microbiol Rev 35: 790–819 [CrossRef] [PubMed].
    [Google Scholar]
  216. Stokes H.W. , Hall R.M. . ( 1989;). A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: integrons. Mol Microbiol 3: 1669–1683 [CrossRef] [PubMed].
    [Google Scholar]
  217. Stokes H.W. , Nesbø C.L. , Holley M. , Bahl M.I. , Gillings M.R. , Boucher Y. . ( 2006;). Class 1 integrons potentially predating the association with Tn402-like transposition genes are present in a sediment microbial community. J Bacteriol 188: 5722–5730 [CrossRef] [PubMed].
    [Google Scholar]
  218. Su H.C. , Ying G.G. , Tao R. , Zhang R.Q. , Fogarty L.R. , Kolpin D.W. . ( 2011;). Occurrence of antibiotic resistance and characterization of resistance genes and integrons in Enterobacteriaceae isolated from integrated fish farms in South China. J Environ Monit 13: 3229–3236 [CrossRef] [PubMed].
    [Google Scholar]
  219. Su H.C. , Ying G.G. , Tao R. , Zhang R.Q. , Zhao J.L. , Liu Y.S. . ( 2012;). Class 1 and 2 integrons, sul resistance genes and antibiotic resistance in Escherichia coli isolated from Dongjiang River, South China. Environ Pollut 169: 42–49 [CrossRef] [PubMed].
    [Google Scholar]
  220. Sun N. , Liu J.H. , Yang F. , Lin D.C. , Li G.H. , Chen Z.L. , Zeng Z.L. . ( 2012;). Molecular characterization of the antimicrobial resistance of Riemerella anatipestifer isolated from ducks. Vet Microbiol 158: 376–383 [CrossRef] [PubMed].
    [Google Scholar]
  221. Sunde M. . ( 2005;). Prevalence and characterization of class 1 and class 2 integrons in Escherichia coli isolated from meat and meat products of Norwegian origin. J Antimicrob Chemother 56: 1019–1024 [CrossRef] [PubMed].
    [Google Scholar]
  222. Sundström L. , Sköld O. . ( 1990;). The dhfrI trimethoprim resistance gene of Tn7 can be found at specific sites in other genetic surroundings. Antimicrob Agents Chemother 34: 642–650 [CrossRef] [PubMed].
    [Google Scholar]
  223. Sundström L. , Vinayagamoorthy T. , Sköld O. . ( 1987;). Novel type of plasmid-borne resistance to trimethoprim. Antimicrob Agents Chemother 31: 60–66 [CrossRef] [PubMed].
    [Google Scholar]
  224. Sundström L. , Swedberg G. , Sköld O. . ( 1993;). Characterization of transposon Tn5086, carrying the site-specifically inserted gene dhfrVII mediating trimethoprim resistance. J Bacteriol 175: 1796–1805 [PubMed].
    [Google Scholar]
  225. Tacão M. , Moura A. , Correia A. , Henriques I. . ( 2014;). Co-resistance to different classes of antibiotics among ESBL-producers from aquatic systems. Water Res 48: 100–107 [CrossRef] [PubMed].
    [Google Scholar]
  226. Tamang M.D. , Oh J.Y. , Seol S.Y. , Kang H.Y. , Lee J.C. , Lee Y.C. , Cho D.T. , Kim J. . ( 2007;). Emergence of multidrug-resistant Salmonella enterica serovar Typhi associated with a class 1 integron carrying the dfrA7 gene cassette in Nepal. Int J Antimicrob Agents 30: 330–335 [CrossRef] [PubMed].
    [Google Scholar]
  227. Taviani E. , Ceccarelli D. , Lazaro N. , Bani S. , Cappuccinelli P. , Colwell R.R. , Colombo M.M. . ( 2008;). Environmental Vibrio spp., isolated in Mozambique, contain a polymorphic group of integrative conjugative elements and class 1 integrons. FEMS Microbiol Ecol 64: 45–54 [CrossRef] [PubMed].
    [Google Scholar]
  228. Tennhammar-Ekman B. , Sköld O. . ( 1979;). Trimethoprim resistance plasmids of different origin encode different drug-resistant dihydrofolate reductases. Plasmid 2: 334–346 [CrossRef] [PubMed].
    [Google Scholar]
  229. Tennstedt T. , Szczepanowski R. , Braun S. , Pühler A. , Schlüter A. . ( 2003;). Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a wastewater treatment plant. FEMS Microbiol Ecol 45: 239–252 [CrossRef] [PubMed].
    [Google Scholar]
  230. Thungapathra M. , Amita, Sinha K.K. , Chaudhuri S.R. , Garg P. , Ramamurthy T. , Nair G.B. , Ghosh A. . ( 2002;). Occurrence of antibiotic resistance gene cassettes aac(6′)-Ib dfrA5 dfrA12, and ereA2 in class I integrons in non-O1, non-O139 Vibrio cholerae strains in India. Antimicrob Agents Chemother 46: 2948–2955 [CrossRef] [PubMed].
    [Google Scholar]
  231. Toleman M.A. , Bennett P.M. , Walsh T.R. . ( 2006a;). ISCR elements: novel gene-capturing systems of the 21st century?. Microbiol Mol Biol Rev 70: 296–316 [CrossRef] [PubMed].
    [Google Scholar]
  232. Toleman M.A. , Bennett P.M. , Walsh T.R. . ( 2006b;). Common regions e.g. orf513 and antibiotic resistance: IS91-like elements evolving complex class 1 integrons. J Antimicrob Chemother 58: 1–6 [CrossRef] [PubMed].
    [Google Scholar]
  233. Traglia G.M. , Almuzara M. , Merkier A.K. , Adams C. , Galanternik L. , Vay C. , Centrón D. , Ramírez M.S. . ( 2012;). Achromobacter xylosoxidans: an emerging pathogen carrying different elements involved in horizontal genetic transfer. Curr Microbiol 65: 673–678 [CrossRef] [PubMed].
    [Google Scholar]
  234. Tseng S.P. , Wang J.T. , Liang C.Y. , Lee P.S. , Chen Y.C. , Lu P.L. . ( 2014;). First Report of bla IMP-8 in Raoultella planticola . Antimicrob Agents Chemother 58: 593–595 [CrossRef] [PubMed].
    [Google Scholar]
  235. Turton J.F. , Kaufmann M.E. , Gill M.J. , Pike R. , Scott P.T. , Fishbain J. , Craft D. , Deye G. , Riddell S. , other authors . ( 2006;). Comparison of Acinetobacter baumannii isolates from the United Kingdom and the United States that were associated with repatriated casualties of the Iraq conflict. J Clin Microbiol 44: 2630–2634 [CrossRef] [PubMed].
    [Google Scholar]
  236. Valenzuela J.K. , Thomas L. , Partridge S.R. , van der Reijden T. , Dijkshoorn L. , Iredell J. . ( 2007;). Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii . J Clin Microbiol 45: 453–460 [CrossRef] [PubMed].
    [Google Scholar]
  237. Van T.T. , Moutafis G. , Tran L.T. , Coloe P.J. . ( 2007;). Antibiotic resistance in food-borne bacterial contaminants in Vietnam. Appl Environ Microbiol 73: 7906–7911 [CrossRef] [PubMed].
    [Google Scholar]
  238. van Essen-Zandbergen A. , Smith H. , Veldman K. , Mevius D. . ( 2007;). Occurrence and characteristics of class 1, 2 and 3 integrons in Escherichia coli Salmonella Campylobacter spp. in the Netherlands. J Antimicrob Chemother 59: 746–750 [CrossRef] [PubMed].
    [Google Scholar]
  239. van Hoek A.H. , Mevius D. , Guerra B. , Mullany P. , Roberts A.P. , Aarts H.J. . ( 2011;). Acquired antibiotic resistance genes: an overview. Front Microbiol 2: 203 [CrossRef] [PubMed].
    [Google Scholar]
  240. Vinué L. , Jové T. , Torres C. , Ploy M.C. . ( 2011;). Diversity of class 1 integron gene cassette Pc promoter variants in clinical Escherichia coli strains and description of a new P2 promoter variant. Int J Antimicrob Agents 38: 526–529 [CrossRef] [PubMed].
    [Google Scholar]
  241. Vo A.T. , van Duijkeren E. , Fluit A.C. , Gaastra W. . ( 2007;). A novel Salmonella genomic island 1 and rare integron types in Salmonella Typhimurium isolates from horses in The Netherlands. J Antimicrob Chemother 59: 594–599 [CrossRef] [PubMed].
    [Google Scholar]
  242. Vo A.T. , van Duijkeren E. , Gaastra W. , Fluit A.C. . ( 2010;). Antimicrobial resistance, class 1 integrons, and genomic island 1 in Salmonella isolates from Vietnam. PLoS One 5: e9440 [CrossRef] [PubMed].
    [Google Scholar]
  243. Waturangi D.E. , Suwanto A. , Schwarz S. , Erdelen W. . ( 2003;). Identification of class 1 integrons-associated gene cassettes in Escherichia coli isolated from Varanus spp. in Indonesia. J Antimicrob Chemother 51: 175–177 [CrossRef] [PubMed].
    [Google Scholar]
  244. White P.A. , McIver C.J. , Deng Y. , Rawlinson W.D. . ( 2000;). Characterisation of two new gene cassettes, aadA5 dfrA17 . FEMS Microbiol Lett 182: 265–269 [CrossRef] [PubMed].
    [Google Scholar]
  245. Wiesner M. , Zaidi M.B. , Calva E. , Fernández-Mora M. , Calva J.J. , Silva C. . ( 2009;). Association of virulence plasmid and antibiotic resistance determinants with chromosomal multilocus genotypes in Mexican Salmonella enterica serovar Typhimurium strains. BMC Microbiol 9: 131 [CrossRef] [PubMed].
    [Google Scholar]
  246. Wright M.S. , Baker-Austin C. , Lindell A.H. , Stepanauskas R. , Stokes H.W. , McArthur J.V. . ( 2008;). Influence of industrial contamination on mobile genetic elements: class 1 integron abundance and gene cassette structure in aquatic bacterial communities. ISME J 2: 417–428 [CrossRef] [PubMed].
    [Google Scholar]
  247. Wu R.B. , Alexander T.W. , Li J.Q. , Munns K. , Sharma R. , McAllister T.A. . ( 2011;). Prevalence and diversity of class 1 integrons and resistance genes in antimicrobial-resistant Escherichia coli originating from beef cattle administered subtherapeutic antimicrobials. J Appl Microbiol 111: 511–523 [CrossRef] [PubMed].
    [Google Scholar]
  248. Wu K. , Wang F. , Sun J. , Wang Q. , Chen Q. , Yu S. , Rui Y. . ( 2012;). Class 1 integron gene cassettes in multidrug-resistant Gram-negative bacteria in southern China. Int J Antimicrob Agents 40: 264–267 [CrossRef] [PubMed].
    [Google Scholar]
  249. Xu Z. , Shi L. , Zhang C. , Zhang L. , Li X. , Cao Y. , Li L. , Yamasaki S. . ( 2007;). Nosocomial infection caused by class 1 integron-carrying Staphylococcus aureus in a hospital in South China. Clin Microbiol Infect 13: 980–984 [CrossRef] [PubMed].
    [Google Scholar]
  250. Xu X. , Kong F. , Cheng X. , Yan B. , Du X. , Gai J. , Ai H. , Shi L. , Iredell J. . ( 2008a;). Integron gene cassettes in Acinetobacter spp. strains from South China. Int J Antimicrob Agents 32: 441–445 [CrossRef] [PubMed].
    [Google Scholar]
  251. Xu Z. , Shi L. , Alam M.J. , Li L. , Yamasaki S. . ( 2008b;). Integron-bearing methicillin-resistant coagulase-negative staphylococci in South China. FEMS Microbiol Lett 278: 223–230 [CrossRef] [PubMed].
    [Google Scholar]
  252. Xu H. , Su Z. , Wang S. , Dai X. , Chen J. , Kong F. , Li Y. , Peng S. , Shao Q. , other authors . ( 2009;). Four novel resistance integron gene-cassette occurrences in bacterial isolates from Zhenjiang, China. Curr Microbiol 59: 113–117 [CrossRef] [PubMed].
    [Google Scholar]
  253. Xu H. , Broersma K. , Miao V. , Davies J. . ( 2011a;). Class 1 and class 2 integrons in multidrug-resistant gram-negative bacteria isolated from the Salmon River, British Columbia. Can J Microbiol 57: 460–467 [CrossRef] [PubMed].
    [Google Scholar]
  254. Xu Z. , Li L. , Shirtliff M.E. , Peters B.M. , Li B. , Peng Y. , Alam M.J. , Yamasaki S. , Shi L. . ( 2011b;). Resistance class 1 integron in clinical methicillin-resistant Staphylococcus aureus strains in southern China, 2001–2006. Clin Microbiol Infect 17: 714–718 [CrossRef] [PubMed].
    [Google Scholar]
  255. Yang C.M. , Lin M.F. , Lin C.H. , Huang Y.T. , Hsu C.T. , Liou M.L. . ( 2009;). Characterization of antimicrobial resistance patterns and integrons in human fecal Escherichia coli in Taiwan. Jpn J Infect Dis 62: 177–181 [PubMed].
    [Google Scholar]
  256. Yang B. , Qu D. , Zhang X. , Shen J. , Cui S. , Shi Y. , Xi M. , Sheng M. , Zhi S. , Meng J. . ( 2010a;). Prevalence and characterization of Salmonella serovars in retail meats of marketplace in Shaanxi, China. Int J Food Microbiol 141: 63–72 [CrossRef] [PubMed].
    [Google Scholar]
  257. Yang H. , Byelashov O.A. , Geornaras I. , Goodridge L.D. , Nightingale K.K. , Belk K.E. , Smith G.C. , Sofos J.N. . ( 2010b;). Characterization and transferability of class 1 integrons in commensal bacteria isolated from farm and nonfarm environments. Foodborne Pathog Dis 7: 1441–1451 [CrossRef] [PubMed].
    [Google Scholar]
  258. Yokoyama E. , Maruyama S. , Kabeya H. , Hara S. , Sata S. , Kuroki T. , Yamamoto T. . ( 2007;). Prevalence and genetic properties of Salmonella enterica serovar typhimurium definitive phage type 104 isolated from Rattus norvegicus Rattus rattus house rats in Yokohama City, Japan. Appl Environ Microbiol 73: 2624–2630 [CrossRef] [PubMed].
    [Google Scholar]
  259. Yu H.S. , Lee J.C. , Kang H.Y. , Ro D.W. , Chung J.Y. , Jeong Y.S. , Tae S.H. , Choi C.H. , Lee E.Y. , other authors . ( 2003;). Changes in gene cassettes of class 1 integrons among Escherichia coli isolates from urine specimens collected in Korea during the last two decades. J Clin Microbiol 41: 5429–5433 [CrossRef] [PubMed].
    [Google Scholar]
  260. Zhao S. , Datta A.R. , Ayers S. , Friedman S. , Walker R.D. , White D.G. . ( 2003;). Antimicrobial-resistant Salmonella serovars isolated from imported foods. Int J Food Microbiol 84: 87–92 [CrossRef] [PubMed].
    [Google Scholar]
  261. Zhao S. , Fedorka-Cray P.J. , Friedman S. , McDermott P.F. , Walker R.D. , Qaiyumi S. , Foley S.L. , Hubert S.K. , Ayers S. , other authors . ( 2005;). Characterization of Salmonella Typhimurium of animal origin obtained from the National Antimicrobial Resistance Monitoring System. Foodborne Pathog Dis 2: 169–181 [CrossRef] [PubMed].
    [Google Scholar]
  262. Zhao S. , McDermott P.F. , White D.G. , Qaiyumi S. , Friedman S.L. , Abbott J.W. , Glenn A. , Ayers S.L. , Post K.W. , Fales W.H. . ( 2007;). Characterization of multidrug resistant Salmonella recovered from diseased animals. Vet Microbiol 123: 122–132 [PubMed].[CrossRef]
    [Google Scholar]
  263. Zhao K.L. , Liu Y. , Zhang X.Y. , Palahati P. , Wang H.N. , Yue B.S. . ( 2011;). Detection and characterization of antibiotic-resistance genes in Arcanobacterium pyogenes strains from abscesses of forest musk deer. J Med Microbiol 60: 1820–1826 [CrossRef] [PubMed].
    [Google Scholar]
  264. Zheng F. , Lin G. , Zhou J. , Cao X. , Gong X. , Wang G. , Qiu C. . ( 2012;). Discovery and characterization of gene cassettes-containing integrons in clinical strains of Riemerella anatipestifer . Vet Microbiol 156: 434–438 [CrossRef] [PubMed].
    [Google Scholar]
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