1887

Abstract

Recently, it has been reported that some non-typable (NT) isolates from Korea and other countries contained a novel gene in the capsular polysaccharide synthesis () locus. In this study, we investigated the presence of in 120 NT isolates from 12 Asian countries; isolate characteristics were also examined. The presence of was assayed by PCR. Clonality of NT isolates containing was investigated by MLST and PFGE. Antimicrobial susceptibility testing was performed and the structure of was also determined. Nineteen NT isolates (15.8 %) were identified as containing : two isolates from Korea, four from Vietnam, two from Hong Kong, eight from Thailand, and one each from Taiwan, the Philippines and Saudi Arabia. Seven isolates from Korea, Vietnam and Thailand were identified as ST1106, whereas just one or two belonged to ST310, ST393, ST10137, ST2754 or ST4136. All but one of the ST1106 NT isolates showed non-susceptibility to penicillin, and all isolates were resistant to cefuroxime, erythromycin, clindamycin and trimethoprim/sulfamethoxazole. The structure of was similar amongst 20 isolates, which had a R1–R2-like region and a variable number of repeats in the repetitive region. However, one isolate (P05-11) from the Philippines lacked the R1–R2 region. NT isolates containing were distributed across several Asian countries. Although MLST analysis suggested that most -containing NT isolates may have emerged independently, ST1106 isolates with the selective advantage of antimicrobial resistance may have disseminated clonally throughout the countries.

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2015-05-01
2019-12-08
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