1887

Abstract

occurs as a range of strains in bald cypress, The organisms live as endophytes in the bark, phloem and xylem, and isolates show differences in cultural and microscopic characteristics on common laboratory media. Many of these fungi make taxol as determined by the reactivity of partially purified culture extracts with specific monoclonal antibodies against taxol. In the case of one strain of (CP-4), taxol was isolated from culture medium and was shown to be identical to authentic taxol by chromatographic and spectroscopic means.

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1996-08-01
2021-10-20
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References

  1. Cardellina J.H. 1991; HPLC separation of taxol and cephalo- mannine. J Liq Chromatogr 14:659–665
    [Google Scholar]
  2. Grothaus P.G., Raybould T.J.G., Bignami G.S., Lazo C.B., Byrnes J.B. 1993; An enzyme immunoassay for the determination of taxol and taxanes in Taxus sp.tissues and human plasma. J Immunol Methods 158:5–15
    [Google Scholar]
  3. Harlow W.M., Harrar E.S. 1950 Textbook of Dendrology. New York: McGraw-Hill;
    [Google Scholar]
  4. Hartzell H. 1991 The Yew Tree. Eugene, OR: Hugolosi Press;
    [Google Scholar]
  5. Liang P., Avenbourk L., Pardee A.B. 1993; Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization. Nucleic Acids Res 21:3269–3275
    [Google Scholar]
  6. McClure T.D, Schram K.M., Reimer M.L.J. 1992; The mass spectroscopy of taxol. Am Soc Mass Spectrom 3:672–679
    [Google Scholar]
  7. Nag T.R. 1993 Coelomycetous Anamorphs with Appendage Bearing Conidia. Waterloo, Ontario: Mycologue Publications;
    [Google Scholar]
  8. Nelson T.A., Toussoun T., Marasas W.F.O. 1983 Fusarium Species. University Park, PA: Penn State University Press;
    [Google Scholar]
  9. Purohit D.K., Chawla G.C. 1989; Fine structure of conidia in two pathogenic species of Pestalotiopsis . Curr Sci 58:659–665
    [Google Scholar]
  10. Stierle A., Strobel G., Stierle D. 1993; Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260:214–216
    [Google Scholar]
  11. Stierle A., Stierle D., Strobel G., Bignami G., Gothaus P. 1994; Bioactive metabolites of the endophytic fungi of Pacific yew, Taxus brevifolia . In Taxane Anticancer AgentsBasic Science Current Status American Chemical Society Symposium Series 583 pp. 81–97 Georg G.I., Chen T.T., Ojima I., Vyas D.M. Edited by Washington, DC: American Chemical Society;
    [Google Scholar]
  12. Strobel G.A., Yang X., Sears J., Kramer R., Sidhu R., Hess W.M. 1996; Taxol from Pestalotiopsis microspora , an endophytic fungus of Taxus wallachiana . Microbiology 142:435–440
    [Google Scholar]
  13. Sun X.A., Ge Q.X., Ling H.Z. 1990; Studies on the criteria of morphological characteristics for species classification of Pestalo¬tiopsis. I.A brief review of nomenclature for the genus Pestalotiopsis and observations on conidia of Pestalotiopsis by SEM. Acta Agric Univ Zhejiangensis 16: Suppl.2 168–172
    [Google Scholar]
  14. Upadhyay R.K., Strobel G.A., Hess W.M. 1991; Morphogenesis and ultrastructure of the conidiomata of Ascochyta cypericola . Mycol Res 95:785–791
    [Google Scholar]
  15. Wani M.C., Taylor H.L., Wall M.E., Coggen P., McPhail A.T. 1971; Plant antitumor agents.VI.The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia . J Am Chem Soc 93:2325–2327
    [Google Scholar]
  16. Young D.H., Michelotti E.J., Swindell C.S., Krauss N.E. 1992; Antifungal properties of taxol and various analogues. Experientia 48:882–885
    [Google Scholar]
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