A large cluster of virulence genes encoding proteins involved in accessory colonization factor (ACF) expression and toxin-coregulated pilus (TCP) biogenesis is flanked by sequences that resemble bacteriophage attachment () half-sites. Adjacent to the -like site is a gene ) that encodes a protein related to the integrase family of site-specific recombinases. The putative vibrio integrase appears to be most closely related to the cryptic prophage (CP4-57) integrase protein (52% identity, 73% similarity). Genomic analysis of numerous strains (O1, non-O1 and O139) revealed that only vibrios capable of causing epidemic Asiatic cholera possess the TCP-ACF colonization gene cluster in association with the integrase. The fact that the integrase gene is absent in avirulent strains suggests that epidemic strains of obtained the TCP-ACF colonization gene cluster via horizontal transfer.


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