Oxygen limitation can induce microbial secondary metabolite formation: investigations with miniature electrodes in shaker and bioreactor culture

References

1. Brown D. E. 1970; Aeration in the submerged culture of micro-organisms. Methods Microbiol l2:125–174
   [Google Scholar]
2. Bu’Lock J. D. 1974 Secondary metabolism of microorganisms. In Industrial Aspects of Microorganisms 1 pp 335–345 Edited by Spencer B. Amsterdam: Elsevier;
   [Google Scholar]
3. Bushell M. E. 1983 Microbiological aspects of the discovery of novel secondary metabolites. In Topics in Enzyme and Fermentation Biotechnolog 6 pp 32–67 Edited by Wiseman A. Glasglow: Blackie;
   [Google Scholar]
4. Bushell M.E. 1988; Growth, metabolism and fermentation technology. In Biotechnology of the Actinomycetale pp 185–215 Edited by Goodfellow M., Williams S. T., Mordarski M. London: Academic Press;
   [Google Scholar]
5. Bushell M. E. 1989 The process physiology of secondary metabolite production. In Microbial products : New Approaches (Society for General Microbiology Symposium no.44) pp 95–120 Edited by Baumberg S., Hunter I. S., Rhodes P. M. Cambridge: Cambridge University Press;
   [Google Scholar]
6. Bushell M. E., Bell S. L., Scott M. F., Snell K., Spier R. E., Wardell J. N., Sanders P. J. 1993; A three phase pattern in growth, monoclonal antibody production and metabolite exchange in a hybridoma bioreactor culture. Biotechnol Bioeng 42:133–139
   [Google Scholar]
7. Chen H. C., Wilde F. 1991; The effect of dissolved oxygen and aeration rate on antibiotic production of Streptomyces fradiae . Biotechnol Bioeng 37:591–595
   [Google Scholar]
8. Demain A. L. 1986 Control of secondary metabolism in Actino-mycetes. In Biological , Biochemical and Biomedical Aspects of Actinomycetes proceedings of the sixth International Symposium on Actinomycetes Biology ,Debrecen, Hungay pp 215–225 Edited by Szabo G., Biro S., Goodfellow M. Budapest: Academiai Kiado;
   [Google Scholar]
9. Freedman D. 1970; The shaker in bioengineering. Methods microbiol 2:175–185
   [Google Scholar]
10. Huck T. A., Porter N., Bushell M. E. 1991; Positive selection of antibiotic-producing soil isolates. J Gen Microbiol 137:2321–2329
    [Google Scholar]
11. Královcová E., Vanek Z. 1979; Effect of aeration efficiency and carbon source on the production of anthrocyclines in Streptomyces galilaeus . Folia Microbiol 24:301–307
    [Google Scholar]
12. Lechevalier M. P., Lechevalier H. A. 1981 Introduction to the order Actinomycetales . In The Prokaryotes pp 1915–1922 Edited by Starr M. P., Stolp M., Trüper H. G., Balows A., Schlegel H. G. Berlin: Springer-Verlag;
    [Google Scholar]
13. McDaniel L. E., Bailey E. G. 1969; Effect of shaking speed and type of closure on shake flask cultures. Appl Microbiol 17:286–290
    [Google Scholar]
14. McDermott J. F., Lethbridge G., Bushell M. E. 1993; Estimation of the kinetic constants and elucidation of trends in growth and erythromycin production in batch and continuous cultures of Saccharopobspora eythraea using curve-fitting techniques. Enzyme Microb Technol 15:657–663
    [Google Scholar]
15. Morimoto T., Itoh H., Chibata I. 1979; Shaking method for tube cultures of microorganisms. Agric Biol Chem 43:15–18
    [Google Scholar]
16. Nisbet L. J. 1982; Current strategies in the search for bioactive microbial metabolites. J Chem Technol Biotechnol 32:251–270
    [Google Scholar]
17. Oner M. D., Erickson L. E., Young S. S. 1986; Utilisation of spline functions for smoothing fermentation data and for estimation of specific rates. Biotechnol Bioeng 28:902–918
    [Google Scholar]
18. Pirt S. J. 1965; Maintenance energy of bacteria in growing cultures. Proc R soc Lond B 163:224–231
    [Google Scholar]
19. Pollitzer L. T., Soutter L. T., Reynolds E. O. R. 1980; Continuous monitoring of natal oxygen tension in infants Four years of experience with an intravascular oxygen electrode. Paediatrics 66:31–36
    [Google Scholar]
20. Rollins M. J., Jensen S. E., Westlake D. W. S. 1988; Effect of aeration on antibiotic production by Streptomyces clavuligerus . J Ind Microbiol 3:357–364
    [Google Scholar]
21. Rollins M. J., Jensen S. E., Wolfe S., Westlake D. W. S. 1990; Oxygen derepresses deacetoxycephalosporin C synthase and increases the conversion of penicillin N to cephamycin C in Streptomyces clavuligerus . Enzme Microb Technol 12:40–45
    [Google Scholar]
22. Sanglier J. J., Haag H., Huck T. A., Fehr T. 1993; Novel bioactive compounds from Actinomycetes: a short review (1988-1992). Res Microbiol 144:633–642
    [Google Scholar]
23. Stanbury P. F., Whitaker A. 1984 Principles of Fermentation Oxford; Pergamon Press:
    [Google Scholar]
24. Tsuji K., Goetz J. F. 1978; High performance liquid chroma-tographic determination of erythromycin. J Chromatogr 147:359–367
    [Google Scholar]
25. Tunac J. B. 1989; High-aeration capacity shake-flask system. J Ferment Bioeng 68:157–159
    [Google Scholar]
26. Uchida M., Sawada H., Asai T., Suzuki M. 1981; Effect of inorganic phosphate and dissolved oxygen on production of maridomycin. J ferment Technol 59:399–401
    [Google Scholar]
27. Vandamme E. J., Leyman D., DeVisscher P., DeBuyser D., Vansteenklste G. 1981; Effect of aeration and pH on gramicidin S prodution by Bacillus bervis . J Chem Technol Biotechnol 31:247–257
    [Google Scholar]
28. Virgilio A., Marcelli E., Agrimino A. 1964; Aeration-agitation studies on the rifamycin fermentation. Biotechnol Bioeng 6:271–283
    [Google Scholar]
29. Woodruff H. B. 1966; The physiology of antibiotic production: the role of the producing organism. In Biochemical Studies of Antimicrobial Drugs (Society for General Microbiology Symposium no. 16) pp 22–46 Edited by Newton B. A., Reynolds P. E. Cambridge; Cambridge University Press:
    [Google Scholar]