RT Journal Article SR Electronic(1) A1 Curran, Brendan P. G. A1 Khalawan, S. A.YR 1994 T1 Alcohols lower the threshold temperature for the maximal activation of a heat shock expression vector in the yeast Saccharomyces cerevisiae JF Microbiology, VO 140 IS 9 SP 2225 OP 2228 DO https://doi.org/10.1099/13500872-140-9-2225 PB Microbiology Society, SN 1465-2080, AB When the yeast Saccharomyces cerevisiae is exposed to elevated growth temperatures, genes containing a heat shock element (HSE) in their promoters are activated. This study demonstrates that alcohols lower the temperature required for the maximal activation of such a promoter and that the concentration of alcohol required decreases as its hydrophobicity increases. A similar correlation has been found between the members of this alcohol series and their effect on a range of membrane functions. Our results therefore indicate that perturbation of the cell membrane may play a role in the heat induced activation of this HSE-containing promoter., UL https://www.microbiologyresearch.org/content/journal/micro/10.1099/13500872-140-9-2225