Summary: Saccharomyces cerevisiae accumulated Co2+ and Cd2+ by two processes: the first, which was metabolism-independent, was presumably cation binding to the cell surface; this was followed by metabolism-dependent, progressive uptake of relatively large amounts of the cations. Two K+ ions were released for each Co2+ ion taken up in freshly prepared cell suspensions whereas extensive loss of cell K+ followed the uptake of Cd2+. Co2+ and Cd2+ appeared to be accumulated via a general cation uptake system, with limited specificity related to the ionic radii of the cations.
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