SUMMARY: In the presence of K, Na enhanced respiration and activated cellular motility and transport of K, amino acids and phosphate in Inorganic phosphate taken up was rapidly esterified to nucleoside triphosphates and diphosphates. Respiration and phosphate transport showed cooperative responses to Na which increased with temperature. Respiration was more sensitive to polymyxin B in the presence of Na. Dinitrophenol and carbonyl cyanide -trifluoromethoxy-phenylhydrazone stimulated respiration when either Na or K was absent, but not in the presence of both cations. Therefore, Na is essential for the cytoplasmic membrane of to perform energy-linked functions coupled to respiration.


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