SUMMARY: The morphological sphere-rod-sphere changes in Arthrobacter crystallopoietes were altered by introducing cyclic AMP into the bacteria. The presence of this cyclic AMP delayed both the formation of the bacillus form and the change back into the coccus form. A specific phosphodiesterase inhibitor, theophylline, also delayed the bacillus formation and the final coccus formation. Cyclic GMP had no demonstrable effect.
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