SUMMARY: Gonococci (strain 3) passaged three times and harvested directly from plastic chambers implanted subcutaneously in guinea pigs were compared with the parent strain () grown The strain grown produced smaller colonies than that grown and when examined directly in chamber fluid was sometimes not pilated. It was more resistant to the bactericidal action of human serum and more infective for guinea-pig chambers. In gel diffusion, extracts of the organisms adapted and cultured once on agar appeared to contain one or two antigens that were different from those in extracts of the grown organisms; and on polyacrylamide gels, electrophoresis of similar extracts showed one or more protein components for strain 3 which were not seen for strain Gonococci grown in guinea-pig subcutaneous chambers appear to be suitable for studies on the determinants of gonococcal pathogenicity.


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