Inhibition of RNA Synthesis in Chlorella and by the Pine-blight Toxin, Dothistromin Free

Abstract

SUMMARY: Dothistromin, an anthraquinone derivative produced by the pine-blight fungus, , inhibits the growth of and At growth inhibitory concentrations, dothistromin strongly inhibits incorporation of [H] uridine into RNA of both species. With , marked inhibition of [H] uridine incorporation is apparent within 5 min of addition of dothistromin, but only a slight inhibition of [H] thymidine incorporation into the DNA-containing fraction or of [C] leucine incorporation into protein is detectable after 10 min.

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1976-08-01
2024-03-28
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