SUMMARY: Dothistromin, an anthraquinone derivative produced by the pine-blight fungus, Dothistroma pini, inhibits the growth of Chlorella pyrenoidosa and Bacillus megaterium. At growth inhibitory concentrations, dothistromin strongly inhibits incorporation of [3H] uridine into RNA of both species. With B. megaterium, marked inhibition of [3H] uridine incorporation is apparent within 5 min of addition of dothistromin, but only a slight inhibition of [3H] thymidine incorporation into the DNA-containing fraction or of [14C] leucine incorporation into protein is detectable after 10 min.
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