1887

Abstract

Summary: Spontaneous mutants of K12 that are resistant to the new aminoglycoside antibiotic, amikacin, were isolated. These mutants have simultaneously acquired cross-resistance to kanamycin, gentamicin and neomycin but not to streptomycin or spectinomycin. Sensitivity of the mutant strains to the non-aminoglycoside antibiotics, ampicillin, tetracycline and polymyxin, was unaffected.

The mutation responsible for amikacin resistance was mapped by P1 transduction and found to be tightly linked to distal with respect to and .

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-94-2-389
1976-06-01
2019-10-21
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-94-2-389
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error