Sensitivity of to Unsaturated Fatty Acids Free

Abstract

Summary: Some unsaturated fatty acids were found to inhibit the growth of . Their effectiveness was related both to the degree of unsaturation and to the configuration of the molecule about the double bonds. Both linoleic acid and linolenic acid increased the proportion of plasmid-negative bacteria in a growing culture of bacteria containing a penicillinase plasmid. This was not due to a curing effect of the fatty acids but was the result of greater sensitivity of the growth of bacteria containing penicillinase plasmid to inhibition by the unsaturated fatty acids. The presence of a plasmid conferring resistance to tetracycline, however, did not make the bacterium more sensitive to inhibition by linoleic or linolenic acids.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-94-2-290
1976-06-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/micro/94/2/mic-94-2-290.html?itemId=/content/journal/micro/10.1099/00221287-94-2-290&mimeType=html&fmt=ahah

References

  1. Dulaney E.L. 1971; Activity of selected compounds against penicillinase-producing Staphylococcus aureus. Transactions of the New York Academy of Sciences 32:843–857
    [Google Scholar]
  2. Dyke K.G.H., Jevons M.P., Parker M.T. 1966; Penicillinase production and intrinsic resistance to penicillins in Staphylococcus aureus. Lancet i:835–838
    [Google Scholar]
  3. Dyke K.G.H., Richmond M.H. 1967; Occurrence of various types of penicillinase plasmid among ‘hospital’ staphylococci. Journal of Clinical Pathology 20:75–79
    [Google Scholar]
  4. Fraenkel G., Hoff H.S. 1940; The physiological action of abnormally high temperatures on poikilothermic animals. Biochemical Journal 34:1085–1092
    [Google Scholar]
  5. Inuzuka N., Nakamura S., Inuzuka M., Tomoeda M. 1969; Specific action of sodium dodecyl sulphate on the sex factor of Escherichia coli K12 Hfr strains. Journal of Bacteriology 100:827–835
    [Google Scholar]
  6. Johnston L.H., Dyke K.G.H. 1971; Stability of penicillinase plasmids in Staphylococcus aureus. Journal of Bacteriology 107:68–73
    [Google Scholar]
  7. Kodicek E. 1956; The effect of unsaturated fatty acids, of vitamin D and other sterols on Gram-positive bacteria. In Biochemical Problems of Lipids pp. 401–406 Edited by Popjak G., le Breton E. London: Butterworths;
    [Google Scholar]
  8. Kodicek E. 1958; Further studies on the effect of linoleic acid on Lactobacillus casei. Journal of General Microbiology 18:xiii
    [Google Scholar]
  9. Kodicek E., Worden A.N. 1945; The effect of unsaturated fatty acids on Lactobacillus helveticus and other Gram-positive organisms. Biochemical Journal 39:78–85
    [Google Scholar]
  10. Kodicek E., Worden A.N. 1946; Effect of unsaturated fatty acids on the acid production of Lactobacillus helveticus. Nature; London: 157587
    [Google Scholar]
  11. Lucy J.A. 1970; The fusion of biological membranes. Nature; London: 227815–817
    [Google Scholar]
  12. Mitsuhashi S., Hashimoto H., Kono M., Morimura M. 1965; Drug resistance of staphylococci. II. Joint elimination and joint transduction of penicillinase production and resistance to macrolide antibiotics. Journal of Bacteriology 89:988–992
    [Google Scholar]
  13. Nieman C. 1954; Influence of trace amounts of fatty acids on the growth of microorganisms. Bacteriological Reviews 18:147–163
    [Google Scholar]
  14. Novick R.P. 1963; Analysis by transduction of mutations affecting penicillinase formation inStaphylococcus aureus. Journal of General Microbiology 33:121–136
    [Google Scholar]
  15. Singer S.J., Nicolson G.L. 1972; The fluid mosaic model of the structure of cell membranes. Science, New York 175:720–731
    [Google Scholar]
  16. Sonstein S.A., Baldwin J.N. 1972; Loss of the penicillinase plasmid after treatment ofStaphylococcus aureus with sodium dodecyl sulphate. Journal of Bacteriology 109:262–265
    [Google Scholar]
  17. Strong F.M., Carpenter L.E. 1942; Preparation of samples for microbiological determination of riboflavin. Industrial and Engineering Chemistry (Analytical Edition) 14:909–913
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-94-2-290
Loading
/content/journal/micro/10.1099/00221287-94-2-290
Loading

Data & Media loading...

Most cited Most Cited RSS feed