1887

Abstract

Summary

Extracellular cyclic AMP-phosphodiesterase accelerates the development of aggregation competence in when present during the pre-aggregation stage. The effect on development appears to depend only on hydrolysis of extracellular cyclic AMP and not on other properties of the phosphodi-esterase molecule. Extracellular cyclic AMP-phosphodiesterase, as a promoter of differentiation, acts mainly throughout the first half of interphase. Our evidence supports the proposal that cyclic AMP oscillations control the rate and possibly the initiation of development. Since extracellular cyclic AMP-phosphodiesterase acts from the beginning of interphase cyclic AMP oscillations may also occur from early interphase, at least in the presence of this enzyme. This would imply that the cyclic AMP oscillator is a determinant, but not a product, of the developmental programme.

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1976-02-01
2024-10-09
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References

  1. Alcântara F., Monk M. 1974; Signal propagation in the cellular slime mould Dictyostelium discoideum. Journal of General Microbiology 85:321–324
    [Google Scholar]
  2. Ashworth J. M. 1971; Cell development in the cellular slime mould Dictyostelium discoideum. Symposia of the Society for Experimental Biology 25: pp. 27–49
    [Google Scholar]
  3. Barkley D. S. 1969; Adenosine-3′-5′-phosphate: identification as acrasin in a species of cellular slime mold. Science; New York: 1651133–1134
    [Google Scholar]
  4. Beug H., Katz F. E., Gerisch G. 1973a; Dynamics of antigen membrane sites relating to cell aggregation in Dictyostelium discoideum. Journal of Cell Biology 56:647–658
    [Google Scholar]
  5. Beug H., Katz F. E., Stein A., Gerisch G. 1973b; Quantitation of membrane sites in aggregating Dictyostelium cells by use of tritiated univalent antibody. Proceedings of the National Academy of Sciences of the United States of America 70:3150–3154
    [Google Scholar]
  6. Bonner J. T. 1970; Induction of stalk cell differentiation by cyclic AMP in the cellular slime mold Dictyostelium discoideum. Proceedings of the National Academy of Sciences of the United States of America 65:110–113
    [Google Scholar]
  7. Bonner J. T., Barkley D. S., Hall E. M., Konijn T. M., Mason J. W., O’Keefe G., Wolfe P. B. 1969; Acrasin, acrasinase, and the sensitivity to acrasin in Dictyostelium discoideum. Developmental Biology 20:72–87
    [Google Scholar]
  8. Bonner J. T., Kelso A. P., Gillmor R. G. 1966; A new approach to the problem of aggregation in the cellular slime molds. Biological Bulletin 130:28–42
    [Google Scholar]
  9. Chassy B. M. 1972; Cyclic nucleotide phosphodiesterase in Dictyostelium discoideum: interconversion of two enzyme systems. Science; New York: 1751016–1018
    [Google Scholar]
  10. Chassy B. M., Love L. L., Krichevsky M. l. 1969; The acrasin activity of 3′-5′-cyclic nucleotides. Proceedings of the National Academy of Sciences of the United States of America 64:296–303
    [Google Scholar]
  11. Cheung W. Y. 1967; Properties of cyclic 3′-5′-nucleotide phosphodiesterase from rat brain. Biochemistry 6:1079–1087
    [Google Scholar]
  12. Davis B. J. 1964; Disc electrophoresis. II. Method and application to human serum proteins. Annals of the New York Academy of Sciences 121:404–427
    [Google Scholar]
  13. Darmon M., Brachet P., Pereira Da Silva L. H. 1975; Chemotactic signals induce cell differentiation in Dictyostelieum discoideum. Proceedings of the National Academy of Sciences of the United States of America 72:3163–3166
    [Google Scholar]
  14. Gerisch G. 1965; Stadienspezifische Aggregationsmuster bei Dictyostelium discoideum. Roux Archiv für Entwicklungsmechanik der Organismen 156:127–144
    [Google Scholar]
  15. Gerisch G. 1968; Cell aggregation and differentiation in Dictyostelium.. In Current topics in Developmental Biology 3 pp. 157–197 Moscona A. A., Monroy A. Edited by New York and London: Academic Press;
    [Google Scholar]
  16. Gerisch G., Fromm H., Huesgen A., Wick U. 1975a; Control of cell-contact sites by cyclic-AMP pulses in differentiating Dictyostelium cells. Nature; London: 255547–549
    [Google Scholar]
  17. Gerisch G., Hess B. 1974; Cyclic-AMP-controlled oscillations in suspended Dictyostelium cells: their relation to morphogenetic cell interactions. Proceedings of the National Academy of Sciences of the United States of America 71:2118–2122
    [Google Scholar]
  18. Gerisch G., Hülsen D., Malchow D., Wick U. 1975b; Cell communication by periodic cyclic-AMP pulses. Philosophical Transactions of the Royal Society B272:181–192
    [Google Scholar]
  19. Gerisch G., Malchow D. 1974; Cell communication and cyclic-AMP regulation during aggregation of the slime mold Dictyostelium discoideum.. In Biochemistry of Sensory Functions pp. 279–298 Jaenicke L. Edited by Berlin, Heidelberg and New York: Springer-Verlag.;
    [Google Scholar]
  20. Gerisch G., Malchow D., Riedel V., Müller E., Every M. 1972; Cyclic AMP phosphodiesterase and its inhibitor in slime mould development. Nature New Biology 235:90–92
    [Google Scholar]
  21. Goidl E. A., Chassy B. M., Love L. L., Krichevsky M. I. 1972; Inhibition of aggregation and differentiation of Dictyostelium discoideum by antibodies against adenosine 3′-5′-cyclic monophosphate diesterase. Proceedings of the National Academy of Sciences of the United States of America 69:1128–1130
    [Google Scholar]
  22. Konijn T. M. 1968; Chemotaxis in the cellular slime moulds. II. The effect of cell density. Biological Bulletin 134:298–304
    [Google Scholar]
  23. Konijn T. M., Raper K. B. 1961; Cell aggregation in Dictyostelium discoideum. Developmental Biology 3:725–756
    [Google Scholar]
  24. Konijn T. M., Barkley D. S., Chang Y. Y., Bonner J. T. 1968; Cyclic AMP: a naturally occurring acrasin in the cellular slime moulds. American Naturalist 102:225–233
    [Google Scholar]
  25. Lin Y. M., Liu Y. P., Cheung W. Y. 1974; Cyclic 3′-5′-nucleotide phosphodiesterase. Purification, characterisation and active form of the protein activator from bovine brain. Journal of Biological Chemistry 249:4943–4954
    [Google Scholar]
  26. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. 1951; Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193:265–275
    [Google Scholar]
  27. Malchow D., Fuchila J., Nanjundiah V. 1975; A plausible role for a membrane-bound cyclic AMP phosphodiesterase in cellular slime mold chemotaxis. Biochimica et biophysica acta 385:421–428
    [Google Scholar]
  28. Malchow D., Gerisch G. 1974; Short-term binding and hydrolysis of cyclic 3′-5′-adenosine monophosphate by aggregating Dictyostelium cells. Proceedings of the National Academy of Sciences of the United States of America 71:2423–2427
    [Google Scholar]
  29. Malchow D., Nägele B., Schwarz H., Gerisch G. 1972; Membrane-bound cyclic AMP phosphodiesterase in chemotactically responding cells of Dictyostelium discoideum. European Journal of Bio-chemistry 28:136–142
    [Google Scholar]
  30. Malkinson A. M., Ashworth J. M. 1973; Adenosine 3′-5′-cyclic monophosphate concentrations and phosphodiesterase activities during axenic growth and differentiation of cells of the cellular slime mould Dictyostelium discoideum. Biochemical Journal 134:311–319
    [Google Scholar]
  31. Michal G., Bergmeyer H. V. 1970 In Methoden der Enzymatischen Analyse, 2nd edn. p. 2060 Bergmeyer H. V. Edited by Weinheim: Verlag Chemie.;
    [Google Scholar]
  32. Newell P. C. 1971; The development of the cellular slime mould Dictyostelium discoideum: a model system for the study of cellular differentiation. Essays in Biochemistry 7:87–126
    [Google Scholar]
  33. Raper K. B. 1950; Pseudoplasmodium formation and organisation in Dictyostelium discoideum. Journal of the Elisha Mitchell Scientific Society 56:241–282
    [Google Scholar]
  34. Riedel V., Gerisch G. 1971; Regulation of extracellular cyclic-AMP-phosphodiesterase activity during development of Dictyostelium discoideum. Biochemical and Biophysical Research Communications 42:119–124
    [Google Scholar]
  35. Riedel V., Gerisch G., Müller E., Beug H. 1973; Defective cyclic adenosine-3′-5′-phosphate- phosphodiesterase regulation in morphogenetic mutants of Dictyostelium discoideum. Journal of Molecular Biology 74:573–585
    [Google Scholar]
  36. Riedel V., Malchow D., Gerisch G., Nägele B. 1972; Cyclic AMP phosphodiesterase interaction with its inhibitor of the slime mould Dictyostelium discoideum. Biochemical and Biophysical Research Communications 46:279–287
    [Google Scholar]
  37. Robertson A., Drage D. J., Cohen M. H. 1972; Control of aggregation in Dictyostelium discoideum by an external periodic pulse of cyclic adenosine monophosphate. Science; New York: 175333–335
    [Google Scholar]
  38. Roos W., Nanjundiah V., Malchow D., Gerisch G. 1975; Amplification of cyclic-AMP signals in aggregating cells of Dictyostelium discoideum. FEBS Letters 53:139–142
    [Google Scholar]
  39. Shaffer B. M. 1956; Acrasin, the chemotactic agent in cellular slime moulds. Journal of Experimental Biology 33:645–657
    [Google Scholar]
  40. Shaffer B. M. 1957; Aspects of aggregation in cellular slime moulds. I. Orientation and chemotaxis. American Naturalist 91:19–35
    [Google Scholar]
  41. Thompson W. J., Appleman M. M. 1971; Multiple cyclic nucleotide phosphodiesterase activities from rat brain. Biochemistry 10:311–316
    [Google Scholar]
  42. Watts D. J., Ashworth J. M. 1970; Growth of myxamoeba of the cellular slime mould Dictyostelium discoideum in axenic culture. Biochemical Journal 119:171–174
    [Google Scholar]
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