@article{mbs:/content/journal/micro/10.1099/00221287-92-1-59, author = "Boucherie, H. and Bégueret, J. and Bernet, J.", title = "The Molecular Mechanism of Protoplasmic Incompatibility and its Relationship to the Formation of Protoperithecia in Podospora anserina", journal= "Microbiology", year = "1976", volume = "92", number = "1", pages = "59-66", doi = "https://doi.org/10.1099/00221287-92-1-59", url = "https://www.microbiologyresearch.org/content/journal/micro/10.1099/00221287-92-1-59", publisher = "Microbiology Society", issn = "1465-2080", type = "Journal Article", abstract = "SUMMARY: In Podospora anserina, protoplasmic incompatibility due to interactions between non-allelic genes was suppressed by the effect of mutations in two modifier genes, mod-1 and mod-2. It is shown that mod-1 and mod-2 are involved in the production of three specific proteins, a phenoloxidase and two previously identified proteases ( Bégueret & Bernet, 1973a ) which are associated with the phenomenon of protoplasmic disintegration. These enzymes, whose messengers are normally latent during vegetative growth, appear at this stage of the life cycle only as a consequence of incompatible gene interactions. The mod-1 and mod-2 genes and each of the five incompatibility loci involved in non-allelic incompatibility systems also participate in the formation of the protoperithecia. This pleiotropic effect suggests that protoplasmic incompatibility is a deviation in the normal physiological processes of protoperithecial formation.", }